Epizyme Outlines Clinical Progress, TAZVERIK Development Strategy and Pipeline Priorities During Company’s Strategic Vision Call
Epizyme, Inc. (Nasdaq: EPZM), a fully integrated, commercial-stage biopharmaceutical company developing and delivering novel epigenetic therapies, hosted a call today outlining the Company’s strategic vision and focus on oncology treatment with the Company’s epigenetic pipeline. A link to the presentation and slideshow can be found here.
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“The recent accelerated approvals of TAZVERIK in Epithelioid Sarcoma and Relapsed / Refractory Follicular Lymphoma are, of course, the critical foundation on which we will continue to expand Epizyme’s mission of rewriting treatments for cancer through novel epigenetic medicines,” said Robert Bazemore, President and Chief Executive Officer of Epizyme. “We believe TAZVERIK has the potential to become a backbone of treatment across lines of ES and FL therapy. Beyond that, we are focused on developing the pipeline-in-a-drug potential we see in TAZVERIK, while expanding our portfolio and bringing novel oncology therapeutics into clinical development. We aspire to change the standard of care for patients and physicians by developing targeted medicines with fundamentally new mechanisms of action directed at specific causes of cancers.”
“I am really excited about Epizyme’s comprehensive and innovative clinical development plan both for tazemetostat and our pipeline, for which we anticipate a steady stream of data,” said Dr. Shefali Agarwal, Epizyme’s, EVP, Chief Medical and Development Officer. “Our aim is to demonstrate the benefits of tazemetostat to patients in earlier lines of treatment for ES and FL by exploring various combinations with standard of care therapies. We also plan to further explore tazemetostat as both monotherapy and in combinations across multiple new hematologic and solid tumor cancers. Our experience and platform have led to an incredibly rich pipeline of both clinical and discovery programs targeting several classes of epigenetic modulators and we expect that many these programs will be entering clinical trials in the next several years.”
Highlights from the Next EPIsode call included:
Preliminary Data from Confirmatory Phase 1b/3 Study EZH-302 in Follicular Lymphoma
The combination of TAZVERIK + R2 (Lenalidomide and Rituximab) is being evaluated in the Phase 1b safety run-in portion of the EZH-302 trial, which enrolled a total of 13 patients. Among the 13 patients evaluated in this standard dose escalation design, no Dose Limiting Toxicities (DLTs) were observed during the first cycle of treatment up to the highest dose of 800mg of TAZVERIK twice daily. As of mid-February, initial data from the trial also showed: