PureTech Founded Entity Akili Collaborates with Weill Cornell Medicine, NewYork-Presbyterian Hospital and Vanderbilt University Medical Center to Study Digital Therapeutic AKL-T01 as Potential Treatment for Patients with COVID Brain Fog - Seite 3

“Clinicians are seeing an increase in cognitive impairments among COVID-19 patients and though we don’t yet know how long these difficulties last, we are concerned about how these cognitive difficulties may affect people in their daily lives,” said Gunning Ph.D., Vice Chair of Research in the Department of Psychiatry, associate professor of psychology in psychiatry at Weill Cornell Medicine, and associate attending psychologist at NewYork-Presbyterian/Weill Cornell Medical Center, who is the study coordinator. “It’s critical that we identify therapeutics to help the increasing number of people whose lives have been impacted by cognitive impairments associated with COVID-19.”

“The chronic symptoms of COVID-19 long haulers represent a serious and growing public health concern that will linger long after the acute nature of COVID-19 has passed,” said James Jackson, PsyD, Assistant Director of The ICU Recovery Center at Vanderbilt and lead psychologist for the Critical Illness, Brain Dysfunction and Survivorship (CIBS) Center at the Vanderbilt University Medical Center. “We’re excited by the potential of new therapeutics that target cognitive impairments to help COVID-19 survivors.”

AKL-T01 is built on the Akili Selective Stimulus Management Engine (SSME), a disease agnostic proprietary technology designed to treat impaired cognitive function, specifically attention control. Delivered through an action video game experience, the first-in-class technology presents specific sensory stimuli and simultaneous motor challenges designed to target and activate the neural systems that play a key role in attention function while using adaptive algorithms to personalize the treatment experience for each individual patient. SSME has been evaluated as a potential treatment for cognitive impairments associated with a number of different disease areas and has been studied in more than 2600 patients across 30 clinical trials. AKL-T01, branded EndeavorRx, is cleared for use by the U.S. Food and Drug Administration (FDA)³ and has received Conformité Européenne (CE) Mark certification in Europe for use in pediatric ADHD⁴. Product screenshots and b-roll are available here.