MaaT Pharma Announces Cash and Revenues for the First Quarter of 2023

Regulatory News:

MaaT Pharma (EURONEXT: MAAT – the “Company”), a clinical-stage biotechnology company and a leader in the development of Microbiome Ecosystem Therapies^TM (MET) dedicated to improving survival outcomes for patients with cancer, today reported its cash position as of March 31, 2023, and its revenues for the first quarter of 2023. The beginning of 2023 was marked by a major milestone in the clinical development of MaaT Pharma, namely the lifting of the clinical hold by the FDA, announced on April 24th, for the Phase 3 trial IND evaluating MaaT013, a microbiome-based drug using the pooling technology.

"In the past 6 months, the microbiome industry has experienced strong momentum, with a very positive news flow, including two market approvals from the FDA for microbiome-derived drugs in infectious diseases," said Hervé Affagard, CEO and co-founder of MaaT Pharma. "We are convinced that our therapeutic approach, combined with our ability to produce MET drug candidates in-house, gives us a significant advantage, especially now that the FDA has for the first time authorized a patented pooling technology for the evaluation in a Phase 3 trial in the United States."

Operational and clinical highlights for the first quarter of 2023:

In January 2023, the Company announced its clinical development roadmap:

• In haemato-oncology: the evaluation of MaaT013 in Graft-versus-Host disease is still progressing in Europe. For MaaT033, the Company continues preparations to initiate the Phase 2b clinical trial dedicated to improving the survival of patients who have received an allo-HSCT² with first sites in France and Germany. Promising clinical data for MaaT013 and MaaT033 were presented in two oral presentations during the 49^th EBMT Annual Meeting that took place in April 2023.
• In immuno-oncology: the Phase 2a proof-of-concept trial sponsored by the AP-HP, evaluating the effect of MaaT013 on the response of immunotherapy treatments in metastatic melanoma, is progressing as planned.
• Neurodegenerative diseases: the Company is expanding its clinical research with a Phase 1b trial in France evaluating MaaT033 in Amyotrophic Lateral Sclerosis (ALS)³, scheduled to start before the end of the first half of 2023.

In February 2023, the Company successfully completed a capital raise of approximately 12.7 million euros with the support of its existing shareholders, extending its cash runway from the fourth quarter of 2023 into the second quarter of 2024.