TransCode Therapeutics CEO Letter to Shareholders - Seite 2

We believe our proprietary therapeutic delivery platform has shown significant potential to address the unmet needs of oncology patients. Through our commitment of harnessing the power of RNA technology, we have created a pipeline of therapeutic candidates using our delivery platform that holds the potential to revolutionize cancer treatments once positive clinical results are achieved. These therapies aim to selectively target cancer cells, enabling precise and personalized approaches that are intended to minimize adverse effects and maximize therapeutic outcomes.

Building on our progress with TTX-MC138, we have focused research and development efforts designed to further optimize and de-risk the delivery platform, enhance the therapeutic profile, and expand our understanding of its mechanisms of action. These ongoing endeavors are crucial to advancing TTX-MC138 into later stages of clinical development and ultimately bringing it to cancer patients who urgently need effective treatment options specific to metastatic disease.

Encouraging progress has been made through additional research and development initiatives involving our diverse therapeutic candidates beyond our lead candidate. We have achieved positive preclinical results with our checkpoint inhibitor, TTX-siPDL1, in pancreatic cancer, as well as promising preclinical results in melanoma with our second immunotherapy candidate, TTX-RIGA, a potential cancer-agnostic therapy. Using our delivery technology, we have created a platform of drug candidates designed to target a variety of tumor types with the objective of significantly improving patient outcomes. In addition to the immunotherapy candidates, we have created TTX-CRISPR, a CRISPR/Cas9–based therapeutic platform for the repair or elimination of cancer-causing genes and TTX-mRNA, an mRNA-based platform for the development of cancer vaccines designed to activate cytotoxic immune responses against tumor cells. Furthermore, we have recently submitted a patent application that encompasses protein delivery, specifically incorporating nanobodies, utilizing our proprietary delivery system with the goal of reaching previously undruggable intra-cellular targets inside cancer cells.