Letter to Shareholders and Corporate Update - Seite 2

I hope that you will agree that these achievements are significant and consistent with the strategy we set forth in our shareholder letter in May. Our focus is on execution and transparency.

Our strategy remains to leverage the two main pillars to our business: the industry-leading research and development organization based here in Liege, Belgium; and our innovative products, the highly differentiated contraceptive, Estelle, and the exciting therapeutic-candidate for symptoms of menopause, Donesta. At the same time, we are actively evaluating the best strategic alternatives for two other non-core businesses owned by Mithra: Novalon, our growing complex therapeutics business, and our state-of-the-art contract development and manufacturing organization (CDMO).

As they have during the past months, Mithra’s businesses will continue to provide access to capital and afford us opportunities to pursue the goals supported by our investors. The most recent financing enables us to enhance our vigorous commercial activities to grow sales of Estelle globally and fund completion of the marketing authorization application for Donesta in the U.S.

We can now also continue investing strongly in Donesta, to further expand on its market potential. We aim to differentiate it in the treatment of menopause symptoms, and to demonstrate clinically that its potential benefits extend to other valuable aspects of women’s health and well-being. We also are evaluating initiation of clinical development in new and valuable additional indications for Estetrol, such as its potential benefit for improving implantation rates during In Vitro Fertilization. A portion of the proceeds has been reserved to support growing our pipeline to include new innovative medicines for women’s health, through internal discovery and/or additional in-licensing.

In summary, the financing was an important step in restoring our balance sheet and another step in our move away from dilutive debt financings towards sources for operating capital, like partnering and equity financing, that create alignment amongst shareholders to support long-term value creation.

Women’s health has traditionally been supported by generic or repurposed medicines, or devices. We believe that there is market demand and great opportunity in bringing innovation back to this therapeutic area, to provide the benefits of impactful new medicines to women of all ages.

To take full advantage of these opportunities, alone or in partnership, we must continue to strengthen Mithra financially. To this end, we have appointed advisors to work vigorously on continuing the restructuring the company’s debt. Our aim is to rapidly rationalize the capital structure and make it more compatible with the exacting criteria of our current supportive investors, as well as the most respected institutional specialist investors in the U.S. and around the world.