RenovoRx CEO Issues Letter to Shareholders - Seite 2

In a further validation of our TAMP platform, in July 2023, we announced a collaboration with Imugene (ASX: IMU) to explore expansion of our TAMP product pipeline with Imugene’s CF33 oncolytic virus therapy for the treatment of difficult-to-access tumors. We are constantly in discussions regarding similar collaborations and potentially out-licenses of RenovoGem as we gear up for the New Drug Application filing (assuming we meet our study endpoints) and commercialization of RenovoGem (if approved by FDA).

As a result of the positive progress that we have made in advancing TAMP with our TIGeR-PaC study, we made important additions to our management team, Board of Directors, and Scientific Advisory Board, bolstering our strong leadership. These additions enhance our already deep expertise resident at RenovoRx.

As we make strong progress on our clinical pathway, it is critically important that we continue to invest in our intellectual property. In December 2023, we filed an additional international patent application under the Patent Cooperation Treaty for our novel TAMP therapy platform. RenovoRx already holds a strong intellectual property portfolio with nine patents issued and nine pending patents for our proprietary TAMP platform and delivery system in the US, EU, and Asia.

This patent application further bolsters the value of TAMP as a novel platform in oncology, beyond our current Phase III clinical asset, and may expand its use into the delivery of larger therapeutic assets across DNA/RNA Altering Modalities, Cell Therapy, and Antibody-Based Therapies. If issued, this new patent will broaden our intellectual property coverage, creating new market potential, while increasing TAMP’s commercial value.

While many companies are tackling cancer treatment in a variety of ways, we believe we are building a better way, with benefits not only for oncology patients, and their clinicians and loved ones, but for our shareholders. There is no question that cancer treatment needs a better, more effective method for drug delivery. Our data thus far suggests that we may be on the forefront of innovating the standard of care for treatment of difficult-to-access tumors. Your support enables our steadfast commitment to improve patients’ lives and lifespans by delivering therapies that have the potential to revolutionize the current paradigm of cancer care.