MaaT Pharma Announces Long Term Follow-Up Data for MaaT013 in Early Access Program to be Presented at the Upcoming EBMT Conference

Regulatory News:

MaaT Pharma (EURONEXT: MAAT – the “Company”), a clinical-stage biotechnology company and a leader in the development of Microbiome Ecosystem Therapies^TM (MET) dedicated to enhancing survival for patients with cancer, will present extended results from its Early Access Program for patients with aGvHD that were treated with MaaT013 and, for the first time, Overall Survival data after 12 months in more patients. The data will be shared during an oral presentation at the 50^th Annual Meeting of the European Society for Blood and Marrow Transplantation held in Glasgow, UK, from April 14-17, 2024. Details from the presentation will be disclosed in a press release on April 17^th, 2024, in compliance with the conference embargo policy.

Aligned with its mission to enhance the survival of cancer patients, MaaT Pharma has been actively involved in the EAP in Europe since 2019. The Company has consistently presented real-world data from its EAP at major hematology conferences over the past four years. At each data communication point, EAP results confirm previous findings, that MaaT013 has an impact on overall survival (OS) when the primary endpoint (gastrointestinal Overall Response Rate at D28) is achieved (see press release on data presented at 2023 ASH^[1] annual meeting). To date, over 220 patients have been treated with MaaT013 in Europe in clinical trials and the EAP.

In the context of the EAP, the Company has bolstered its manufacturing & supply chain, ensuring timely and safe provision of MaaT013 to 38 stem cell transplant hospitals across 6 European countries: Austria, Belgium, France, Germany, Italy, and Spain.

Dr. Michael Loschi, hematologist at Nice Hospital in France emphasized “we are enrolling in the EAP due to the lack of third-line treatment options for patients with aGvHD who are unresponsive to corticosteroids and ruxolitinib. We receive MaaT013 within 48 hours following the request via a simple procedure for EAP. This has transformed our routine to treating patients with aGvHD and significantly improved their quality of life. The data presented at ASH align with our observations in clinical practice. We've observed superior efficacy with more complete responses^[2] in gastrointestinal aGvHD and less toxicity when compared to other immune suppressive drugs."