Century Therapeutics Presents Preclinical Data Highlighting Advances in iPSC Platform Technology and Programs at 2024 ASGCT Annual Meeting

• In vitro data showcases CNTY-101’s ability to induce CD19-specific cytolysis of B-cells and potential to treat B-cell driven autoimmune diseases including systemic lupus erythematosus (SLE)
  
• Preclinical data demonstrates potential utility of using a synthetic ligand targeting CD300a as a universal strategy for preventing NK mediated rejection in allogeneic cell therapies

PHILADELPHIA, May 10, 2024 (GLOBE NEWSWIRE) -- Century Therapeutics (NASDAQ: IPSC), an innovative biotechnology company developing induced pluripotent stem cell (iPSC)-derived cell therapies in immuno-oncology and autoimmune and inflammatory disease, today announced two poster presentations at the ASGCT 27^th Annual Meeting. The data presented highlights the potential of the Company’s lead candidate, CNTY-101, to treat B-cell driven autoimmune diseases including SLE. Additionally, the Company presented data which further demonstrates the capabilities of its Allo-Evasion technology through new preclinical data of a CD300a agonist which can potentially inhibit natural killer (NK) cell alloreactivity.

“As demonstrated today, we remain dedicated to continuously investing in the evolution of our Allo-Evasion platform to further enable our iPSC candidates to have a more controlled, durable and tolerable profile than other cell therapies currently in development to treat autoimmune disease,” said Hy Levitsky, M.D., President of Research and Development at Century Therapeutics. “The data demonstrate CNTY-101, an allogeneic iPSC-derived NK cell therapy engineered using Allo-Evasion edits, eliminates CD19+ B-cells in vitro while enhancing persistence and durability with less inflammatory cytokine secretion after target killing. We are also excited to highlight preclinical data of a novel synthetic ligand to CD300a, a potent inhibitory receptor found in nearly all NK cells tested across a wide sampling of the population to render engineered cells resistant to NK cell mediated rejection, potentially offering greater protection for a variety of allogeneic cell therapies currently in development. Together, these capabilities have the potential to allow us not only to protect allogeneic cell therapies better than leading alternatives, but also improve outcomes and deliver a broadly beneficial treatment option across a range of indications.”