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Merck Highlights New Data from Leading Lung Cancer Clinical Development Program at the IASLC 2019 World Conference on Lung Cancer

Nachrichtenquelle: Business Wire (engl.)
22.08.2019, 12:45  |  217   |   |   

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced new data from the company’s leading clinical development program in lung cancer will be presented at the IASLC 2019 World Conference on Lung Cancer (WCLC) hosted by the International Association for the Study of Lung Cancer in Barcelona, Spain from Sept. 7-10, 2019. More than 30 abstracts evaluating KEYTRUDA, Merck’s anti-PD-1 therapy, in combination with other cancer therapies and as monotherapy, will be presented. Key data to be presented in non-small cell lung cancer (NSCLC) include new pooled findings from three trials – KEYNOTE-189, KEYNOTE-407 and KEYNOTE-021 (cohort G) - evaluating KEYTRUDA in combination with chemotherapy among a subgroup of patients whose tumors do not express PD-L1. Three-year overall survival (OS) data with KEYTRUDA monotherapy from KEYNOTE-024 will also be presented and was selected for inclusion in the official WCLC press program.

“Our robust lung cancer clinical development program continues to demonstrate that KEYTRUDA provides a foundation for the treatment of non-small cell lung cancer,” Dr. Jonathan Cheng, vice president, oncology clinical research, Merck Research Laboratories. “At this year’s World Conference on Lung Cancer, we look forward to presenting new and updated data that further reinforce the overall survival benefit of KEYTRUDA, in combination with chemotherapy or as monotherapy, in appropriate patients with advanced non-small cell lung cancer.”

Key oral data presentations include:

  • First presentation of pooled data from a subgroup of patients whose tumors do not express PD-L1 from the randomized KEYNOTE-189, KEYNOTE-407 and KEYNOTE-021 (cohort G) studies evaluating KEYTRUDA in combination with chemotherapy as first-line treatment in patients with advanced nonsquamous and squamous NSCLC (Abstract #MA25.01) will be presented in a mini oral session on Tuesday, Sept. 10, 2:30-2:37 p.m. CEST.
  • Three-year OS data from the pivotal Phase 3 KEYNOTE-024 study evaluating KEYTRUDA monotherapy as first-line treatment in patients with advanced NSCLC whose tumors express PD-L1 (tumor proportion score [TPS] ≥50%) (Abstract #OA14.01) will be presented in an oral session on Tuesday, Sept. 10, 11:30-11:40 a.m. CEST and highlighted in the official WCLC press program.
  • First presentation of data from a cohort of Chinese patients enrolled in the pivotal Phase 3 KEYNOTE-042 study evaluating KEYTRUDA monotherapy as first-line treatment in patients with advanced NSCLC whose tumors express PD-L1 (TPS ≥1%) (Abstract #MA11.02) will be presented in a mini oral session on Monday, Sept. 9, 2:05-2:10 p.m. CEST.
  • First presentation of tissue tumor mutational burden (tTMB) data from the pivotal Phase 3 KEYNOTE-189 study evaluating KEYTRUDA in combination with pemetrexed (ALIMTA) and platinum chemotherapy as first-line treatment in patients with metastatic nonsquamous NSCLC (Abstract #OA04.06) will be presented in an oral session on Sunday, Sept. 8, 4:10-4:20 p.m. CEST and highlighted in the official WCLC press program.
  • First presentation of tTMB data from the Phase 1/2 KEYNOTE-021 study evaluating KEYTRUDA in combination with platinum chemotherapy as first-line treatment in patients with metastatic nonsquamous NSCLC (Abstract #OA04.05) will be presented in an oral session on Sunday, Sept. 8, 4:00-4:10 p.m. CEST and highlighted in the official WCLC press program.

Other select abstracts to be presented from Merck’s clinical development program include:

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