Arcutis Enrolls Last Patient in Phase 2b Clinical Trial Evaluating ARQ-154 (Topical Roflumilast Foam) as a Potential Treatment for Scalp Psoriasis - Seite 2

Arcutis believes roflumilast foam has significant potential as a scalp psoriasis treatment.  Roflumilast foam is nearly identical to ARQ-151 (topical roflumilast cream), Arcutis’ topical cream PDE4 inhibitor that has demonstrated statistically significant improvements of psoriasis symptoms and a favorable tolerability profile in two separate Phase 2 studies.  Psoriasis plaques on the scalp are identical to plaques elsewhere on the body, so the roflumilast cream psoriasis results should be highly predictive.

The Phase 2b trial in scalp psoriasis is an 8-week, multi-center, multi-national, double blind, vehicle-controlled, study of the safety and efficacy of topical roflumilast foam 0.3% administered once-daily in approximately 300 adult and adolescent patients with plaque psoriasis that includes plaques on the scalp. The primary endpoint of the trial is achievement of an Investigator Global Assessment score of 'clear' or 'almost clear' plus a 2-grade improvement from baseline on the scalp (S-IGA) at week 8. Multiple secondary endpoints will also be evaluated.

About Scalp Psoriasis
Scalp psoriasis is a manifestation of plaque psoriasis characterized by raised, red areas of skin (“plaques”) covered with a silver or white scale that occurs in the hair-bearing area of the scalp and sometimes extending to the forehead, back of the neck, or behind or inside the ears.  Patients with scalp psoriasis commonly have plaques on other areas of the body as well.  Nearly half of the estimated 8.6 million Americans with psoriasis have involvement of the scalp.  Scalp psoriasis plaques are identical to psoriatic plaques on other areas of the body, however topical treatment of scalp plaques is complicated by the difficulty of delivering topical drugs under the hair and onto the skin. As with psoriatic plaques on other parts of the body, psoriasis on the scalp is often itchy and is sometimes painful. Scalp psoriasis can also be associated with hair loss, likely due to damage to the hair from excessive scratching, rubbing, or combing of the affected area.

About Arcutis - Bioscience, applied to the skin.
Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT) is a late-stage biopharmaceutical company focused on developing and commercializing treatments for unmet needs in immune-mediated dermatological diseases and conditions, or immuno-dermatology. The company is leveraging recent advances in immunology and inflammation to develop differentiated therapies against biologically validated targets to solve persistent treatment challenges in serious diseases of the skin. Arcutis’ robust pipeline includes four novel drug candidates currently in development for a range of inflammatory dermatological conditions. The company’s lead product candidate, topical roflumilast, has the potential to revitalize the standard of care for plaque psoriasis, atopic dermatitis, scalp psoriasis, and seborrheic dermatitis.  For more information, visit https://www.arcutis.com or follow the company on LinkedIn and Twitter.