Kezar Life Sciences to Present at Four Upcoming Virtual Medical and Scientific Conferences - Seite 2

Kezar’s presentation will focus on the potential use of narrow-spectrum inhibitors of Sec61 for attenuation of the secretion of multiple pro-inflammatory cytokines in vitro and in vivo, with limited cytotoxicity.

Title: Blockade of Cytokine Production and Attenuation of Experimental Arthritis Progression by Novel Small Molecule Inhibitors of Sec61-Dependent Protein Secretion
Session: Lightning Talk Session 2: Autoinflammation and autoimmunity
Presenter: Janet L. Anderl, MS, Senior Scientist, Kezar Life Sciences
Date: November 2, 2020, 6:15 – 8:15 pm ET

American College of Rheumatology’s Convergence 2020

Dr. Richard Furie will present updated interim results of the MISSION Phase 1b study of KZR-616 in SLE patients with and without nephritis in a poster session. Additionally, Marta Del Rio Olivia will give an oral presentation featuring preclinical data on the mechanism of KZR-616 in a murine model of polymyositis.

Title: Treatment of SLE with or without Nephritis with the Immunoproteasome Inhibitor KZR-616: Updated Results of the MISSION Study
Abstract N°: 0855
Session: SLE – Treatment Poster I
Presenter: Richard Furie, M.D., Chief of the Division of Rheumatology at Northwell Health
Date: November 7, 2020, 9:00 – 11:00 am ET

Title: KZR-616, a First-in-class Selective Inhibitor of the Immunoproteasome, Ameliorates Polymyositis in a Murine Model
Abstract N°: 1916
Session: Systemic Sclerosis & Related Disorders – Basic Science Poster
Presenter: Marta Del Rio Oliva, Ph.D. candidate, Clinical Immunology, University of Konstanz
Date: November 9, 2020 at 9:00 – 11:00 am ET

The Society for Immunotherapy of Cancer’s Annual Meeting

Kezar Life Sciences will present a scientific poster demonstrating that Sec61 inhibitors can block the expression of CD47, a phagocytosis checkpoint protein, on tumor cells and subsequently modulate macrophage phagocytic activity.

Title: Small molecule inhibitors of Sec61 co-translational translocation regulate the phagocytosis checkpoint molecule CD47
Abstract N°: 207
Session: Checkpoint Blockcade Therapy - poster session
Presenter: Jennifer Whang, Ph.D., Senior Scientist, Kezar Life Sciences
Date: November 11, 5:15 – 5:45pm ET; November 13, 4:40-5:10pm ET

About KZR-616

KZR-616 is a novel, first-in-class, selective immunoproteasome inhibitor with broad therapeutic potential across multiple autoimmune diseases. Preclinical research demonstrates that selective immunoproteasome inhibition results in a broad anti-inflammatory response in animal models of several autoimmune diseases, while avoiding immunosuppression. Data generated from Phase 1a and 1b trials provide evidence that KZR-616 exhibits a favorable safety and tolerability profile for development in severe, chronic autoimmune diseases. Phase 2 trials are underway in severe autoimmune diseases.