Intellia Therapeutics Announces Presentations at the 24th American Society of Gene and Cell Therapy Annual Meeting

- Updated preclinical data will be presented on CRISPR/Cas9-mediated targeted gene insertion to treat alpha-1 antitrypsin deficiency (AATD)

CAMBRIDGE, Mass., April 27, 2021 (GLOBE NEWSWIRE) -- Intellia Therapeutics, Inc. (NASDAQ:NTLA), today announced the presentation of new data from its CRISPR/Cas9 platform at the 24^th American Society of Gene & Cell Therapy (ASGCT) Annual Meeting, taking place virtually from May 11-14, 2021.

“The data accepted for presentation at ASGCT reflects our ongoing commitment to finding new ways to treat and potentially cure a variety of diseases. Utilizing our modular in vivo insertion technology, we demonstrate the potential to durably restore normal AAT protein levels after a single dose. We continue to advance multiple genome editing strategies for patients living with AATD,” said President and Chief Executive Officer John Leonard, M.D. “In a separate presentation, Intellia will share our integrative genomics approach that combines computational, biochemical and cell-based genome-wide off-target discovery as well as characterization of potential DNA structural variants to identify precise CRISPR/Cas9 sequences that are safe human therapeutic candidates.”

ASGCT Annual Meeting Presentations & Invited Sessions

Oral Presentation:

Title: “CRISPR/Cas9-Mediated Targeted Gene Insertion Platform Achieves Durable, Normal Human Alpha-1 Antitrypsin Protein Levels in Non-Human Primates”
Abstract number: 15
Session Title: Delivery Technologies and CRISPR for Therapeutics
Session Room: Room 3
Date and Time: Tuesday, May 11, 2021, 5:30 – 5:45 p.m. ET
Presenting Author: Sean Burns M.D., vice president of Intellia’s Disease Biology and Pharmacology group

Invited Talks:

Title: “Characterization of Potential Unintended Genome Editing with CRISPR/Cas9 for New Therapeutics”
Session Type: Pre-Meeting Program
Session Title: Moving Genome Editing to the Clinic: from Technology to Therapeutics
Date and Time: Monday, May 10, 2021, 1:05 – 1:30 p.m. ET
Presenting Author: Daniel O’Connell Ph.D., director of Intellia’s platform development group

Title: “Development of Systemic CRISPR-Based Therapeutics”
Session Title: Genome Editing – Clinical and Preclinical Updates
Date and Time: Tuesday, May 11, 2021, 10:26 – 10:52 a.m. ET
Presenting Author: Laura Sepp-Lorenzino, Ph.D., chief scientific officer

Additional data collected will be included in final meeting presentations. All abstracts for the ASGCT Annual Meeting are available on ASGCT’s website here.