Twist Bioscience Collaborates with Regeneron for Production of Genotyping by Sequencing Panel to Enable Diverse Genome-wide Screening - Seite 2

“While SNP microarray has been the gold standard of genetic study, we have more and more customers asking for a complete genotyping solution that allows flexibility for customized disease research and we believe this is the future of disease marker testing,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “Collaborating with Regeneron to optimize the assay with content from multiple ethnicities enables increased characterization of diverse populations to improve understanding around disease and potentially therapeutic development as well. We’re pleased to bring the Twist Diversity SNP assay to the scientific community.”

The Diversity SNP assay also enables research centers to consolidate their data generation costs and physical footprints by leveraging next-generation sequencers for both genotyping and exome/custom panels rather than maintaining separate genotyping instrumentation and lab space. While microarrays provide information about the presence or absence of a genetic variant, the Diversity SNP panel produces dynamic, multi-faceted information across a broad spectrum of the population. In addition, the panel can be iterated quickly to build a customized assay incorporating real-time journal and database entries.

About the Twist Diversity SNP Panel

As the first release in Twist’s emerging Targeted Genotyping-By-Sequencing (GBS) portfolio, the Twist Diversity SNP panel leverages Twist’s best-in-class DNA synthesis platform to generate a global panel of more than 600,000 probes governing approximately 1.4 million SNPs. Used separately as a stand-alone genotyping panel or as an addition (spike-in) into Twist’s Human Comprehensive Exome panel, this assay gives researchers a new ethnicity-neutral gold standard to use in generating genotyping data to match with their sequencing and other genomic data. Compared to historical microarray platforms that offer fixed content updated occasionally, the Twist Diversity SNP panel allows scientists the freedom to choose between standardized catalogue content or - with Twist’s custom NGS probes capabilities - the ability to build upon this foundation with additional regions of interest, creating unique content for any focused disease research application. For higher throughput users, this approach also enables improved scale-up economics with no requirement for additional capital investment.