BioInvent Outlines Strong Progress in Clinical and Preclinical Pipeline at R&D Day 2022 - Seite 2

BioInvent is also moving several other drug candidates through clinical and preclinical development. The latest updates include:

• Recruitment to both the single agent and combination arms of the Phase 1/2a trial with the anti-TNFR2 drug candidate BI-1808 is progressing well, with two patients already dosed with 1000mg. Interim results from the trial, which is evaluating BI-1808 as a single agent and in combination with the anti-PD-1 therapy Keytruda® (pembrolizumab) in patients with ovarian cancer, non-small cell lung cancer and cutaneous T-cell lymphoma (CTCL), have reinforced the very favorable tolerability profile, no safety concerns and early signs of efficacy.
• A joint paper on BT-001, a vectorized anti-CTLA-4 antibody co-developed with Transgene and currently in a Phase 1/2a trial, has won this year's Journal for ImmunoTherapy of Cancer (JITC) Best Oncolytic and Local Immunotherapy Paper Award. The trial assessing BT-001 as a single agent and in combination with Keytruda against solid tumors is progressing well, and BioInvent and Transgene plan to present results from Part A at a scientific conference H1 2023.
• The U.S. Food and Drug Administration (FDA) has approved BioInvent's Investigational New Drug (IND) application for its FcyRIIB-blocking antibody BI-1607. This allows for the ongoing Phase 1/2a trial of BI-1607 in combination with trastuzumab in HER2+ solid tumors to be extended to U.S. centers. The ongoing clinical study is progressing well with the first dose cohort (75 mg) completed with no safety or tolerability concerns and no infusion-related reactions observed.
• Preclinical development of the anti-TNFR2 antibody BI-1910 continues as planned. While BI-1808 is a ligand blocking FcyR-engaging anti-TNFR2 antibody, BI-1910 has FcyR-independent intrinsic agonist activity.

BioInvent is hosting the R&D Day in Stockholm at 2:00 pm CET, Thursday December 8, 2022. Further details can be found on BioInvent's website www.bioinvent.com.

About BioInvent
BioInvent International AB (Nasdaq Stockholm: BINV) is a clinical-stage biotech company that discovers and develops novel and first-in-class immuno-modulatory antibodies for cancer therapy, with currently four drug candidates in five ongoing clinical programs in Phase 1/2 trials for the treatment of hematological cancer and solid tumors, respectively. The Company's validated, proprietary F.I.R.S.T™ technology platform identifies both targets and the antibodies that bind to them, generating many promising new drug candidates to fuel the Company's own clinical development pipeline and providing licensing and partnering opportunities.