Altamira Therapeutics’ SemaPhore Delivery Platform Shows Significant Synergis-tic Effects of ZBTB46 mRNA with PD1 Immunotherapy in Control of Tumor Growth in Animal Model - Seite 2

Samuel Wickline, M.D., Altamira’s Chief Scientific Adviser and a co-author of the manuscript, commented: “The tumor microenvironment is known to play a key role in cancer growth. This latest study from the Choi Lab not only identified ZBTB46 as a key element in the interaction between tumor growth and tumor microenvironment, but also demonstrated how boosting its expression by using mRNA can help to attenuate tumor growth. In addition, it showed very promising synergistic effects with a well-known immune checkpoint inhibitor. Our SemaPhore nanoparticles have been designed to reach target diseased cells with systemic administration and efficiently deliver mRNA therapeutics inside those cells, and we believe that there is significant potential for them supporting the development of novel cancer treatment options.”

About SemaPhore

SemaPhore is a versatile platform designed to allow for safe and effective delivery of mRNA (messenger ribonucleic acid) into target cells. It is based on a patented 21-amino acid peptide that can engage any type of RNA in rapid self-assembly into a polyplex. The polyplex has a size, charge, and other physical features that allow it to escape hepatic clearance and thus to reach other target tissues than the liver. SemaPhore protects the RNA payload from degradation in the circulation and allows for rapid cellular uptake, while enabling pH-dependent nucleotide endosomal escape and cytoplasmic delivery. Effective delivery of mRNA and positive treatment outcomes have been demonstrated in various murine models of disease, including osteoarthritis (WNT16), atherosclerosis (p27^Kip1) and aortic aneurysm (SOD2).

About Altamira Therapeutics

Altamira Therapeutics (Nasdaq:CYTO) is dedicated to developing RNA-based therapeutics for extrahepatic targets (OligoPhore / SemaPhore delivery platforms). The Company currently has two flagship siRNA programs in preclinical development beyond in vivo proof of concept: AM-401 for KRAS driven cancer and AM-411 for rheumatoid arthritis. The versatile delivery platform is also suited for mRNA and other types of RNA therapeutics and shall be leveraged via out-licensing to pharma or biotech companies. In addition, Altamira is in the process of divesting and/or licensing-out its legacy assets in allergology and viral infection (Bentrio OTC nasal spray; commercial) and inner ear therapeutics (AM-125 nasal spray for vertigo; post Phase 2; Keyzilen and Sonsuvi for tinnitus and hearing loss; Phase 3). Founded in 2003, Altamira is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: https://altamiratherapeutics.com/