Wave Life Sciences Highlights Recent Achievements and Upcoming 2024 Milestones

Multiple data catalysts across all clinical programs expected throughout 2024, including data for WVE-006 in AATD which would provide first-ever RNA editing proof-of-mechanism in humans

Selection of clinical candidate for GalNAc-siRNA INHBE program in obesity now planned for 3Q 2024, ahead of prior expectation; designed to reduce fat, spare muscle mass, and restore and maintain a healthy metabolic profile

Dosing underway in potentially registrational FORWARD-53 trial evaluating WVE-N531 in DMD; 24-week data, including dystrophin from muscle biopsies, expected in 3Q 2024

WVE-003 30 mg Q8W multi-dose data with extended follow-up on track for 2Q 2024; most advanced program designed to lower mutant HTT while also sparing wild-type HTT

Well-capitalized following $142 million of cash inflows in 4Q 2023, including $115 million from December financing and $27 million in collaboration milestone payments; poised to deliver and advance innovative and sustainable pipeline and unlock significant value

CAMBRIDGE, Mass., Jan. 08, 2024 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, today announced key 2024 milestones across its clinical programs, growing pipeline, and leading RNA medicines platform.

“Wave is uniquely positioned to build the world’s leading RNA medicines company, with a clinically validated platform, diversified pipeline aimed at high-impact diseases, and meaningful commercial opportunities. Powered by multiple RNA modalities, a decade of chemistry innovation, and deep genetic insights, we are opening up new areas of disease biology and designing optimal ways of treating rare and common diseases. We expect 2024 will be an inflection year that will drive significant value for Wave, our shareholders, and most importantly, for the patients who will benefit from our research,” said Paul Bolno, MD, MBA, President and Chief Executive Officer of Wave Life Sciences.

Dr. Bolno continued: “This year, we expect the first-ever clinical proof-of-mechanism data for RNA editing with WVE-006 in AATD, which will accelerate additional Wave RNA editing programs. We are rapidly advancing our wholly owned INHBE program for obesity, which is designed to enable healthy, sustainable fat loss and address limitations of GLP1s. We also expect to deliver data demonstrating production of endogenous dystrophin protein in DMD with WVE-N531, as well as multidose data for WVE-003, our HD candidate that is uniquely designed to lower mutant huntingtin and maintain healthy, wild-type huntingtin. These programs underscore our drive to ‘Reimagine Possible’ for science, for medicine, and for human health.”