Video: Give Someone a Fish, You Feed Them - Unlock the Fish Genome, You Feed the World - Seite 2

Decisions about which pairs to breed can be made significantly faster, and more accurately, if they know their fish's genetic information-and they've found just the right partner to unlock this knowledge.

The Earlham Institute: Finding the right genes for the job
The Earlham Institute is a life science research hub in Norwich, England, that uses genomics to decode the scale and complexity of living systems. Karim Gharbi, its head of Genomics Pipelines, researched genetic markers in fish for his PhD-he credits his career to a lifelong fascination with the documentaries of Jacques Cousteau.

His colleague Tarang Mehta is a postdoctoral researcher seeking to understand the basis of gene regulation in fish, specifically how some genes are linked to better salinity adaptation in certain tilapia species but not others. He hopes that, with sufficient genomic information, WorldFish could breed tolerance to fluctuating salinity into species that are farmed in developing countries.

The Earlham Institute isolates their DNA samples from tiny pieces of fin collected from live fish across the world and sequences them using the Illumina NovaSeq X Plus System. Then, by analyzing the generated data, they can identify genetic markers that express desirable traits.

Among those traits, disease resistance may be the most critical-tilapia lake virus alone is responsible for up to 90% of tilapia mortality worldwide. "Once we have a disease developing in a particular farming industry like aquaculture," Gharbi said, "this can start spreading from farm to farm, and every outbreak event is a loss to the farmer. The faster we can help farmers grow fish less susceptible to disease, the less income they will lose."

Having access to an animal's genome is a breakthrough that changes how organizations like WorldFish can operate: Previously, breeders had to directly expose fish to a virus in order to select individuals who showed better resistance to it. Now they can avoid this step, arriving at answers faster and without causing unnecessary harm.

The NovaSeq X Series: Fast, accurate, and sustainable
The Earlham Institute serves many users in the UK and beyond who depend on them to generate high-quality data quickly, affordably, and sustainably, and Gharbi and Mehta both attest to the NovaSeq X Series' strengths in that arena.

Under optimal conditions, Gharbi said, they can receive samples from WorldFish and return results within five days. And in a recent evaluation of the institute's "green impact," the NovaSeq X Series' sustainable reagents helped them demonstrate their efforts to reduce waste.

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