Savara Presented New Data on Autoimmune Pulmonary Alveolar Proteinosis (aPAP) at the American Thoracic Society (ATS) International Conference 2024

Savara Inc. (Nasdaq: SVRA) (the Company), a clinical stage biopharmaceutical company focused on rare respiratory diseases, presented a poster at the American Thoracic Society (ATS) 2024 International Conference that is taking place May 17-22, 2024, in San Diego, CA. Savara’s partner, Trillium Health LLC, presented a poster on the laboratory blood test that was recently developed to aid in the diagnosis of aPAP.

Below are summaries of the posters presented:

Poster Board 701: “Healthcare Burden of Pulmonary Alveolar Proteinosis” presented by E. Lee, M.D., Ph.D.; sponsored by Savara Inc.

• Presented data from a retrospective cohort analysis using a longitudinal claims database (IPM.ai) comparing the clinical and economic burden of a sample of 2,312 pulmonary alveolar proteinosis (PAP) patients to 9,247 non-PAP matched controls.
• Data demonstrated PAP patients experience higher healthcare resource utilization and higher pharmaceutical and non-pharmaceutical costs as evidenced by a 4-fold increase in hospital admissions, 6-fold increase in in-patient visits, and a 4-fold increase in cost of care, as well as higher rates of comorbidities, procedures, and therapy use (all parameters p<0.001), thereby highlighting a significant unmet need in this rare disease patient population.
• Click here to view the abstract.
• Lee E, Ataya A, McCarthy C, Cosenza J, Bielecki S, Wang TS. Healthcare burden of pulmonary alveolar proteinosis. Am J Respir Crit Care Med 2024;209:A1173.

Poster Board 702: “Development of a Novel Laboratory Test for the Detection of GM-CSF Antibodies to Aid in the Diagnosis of Individuals At-risk for Autoimmune Pulmonary Alveolar Proteinosis (aPAP)” presented by A. Ali and J. Kim of Trillium Health LLC

• Presented data on the development and performance characteristics of a novel laboratory test for the detection of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in human serum to aid in the diagnosis of aPAP.
• Clinical accuracy of 100% was achieved in a cohort of 40 subjects (negative cohort n=20, positive cohort n=20), demonstrating Trillium’s particle-based flow cytometry immunoassay test offers a highly precise and sensitive laboratory test for the determination of GM-CSF antibody levels in human serum and, thus, can successfully be used as a tool to definitively diagnose aPAP.
• Click here to view the abstract.
• Kim J, Cornish D, Ali A. Development of a novel laboratory test for the detection of GM-CSF antibodies to aid in the diagnosis of individuals at-risk for autoimmune pulmonary alveolar proteinosis (aPAP). Am J Respir Crit Care Med 2024;209:A1174.

The full content of these posters is available in the Articles and Publications page of the Savara corporate website. Additionally, the abstracts are published in a supplement of the American Journal of Respiratory and Critical Care Medicine (AJRCCM). For more details about the ATS International Conference please visit https://conference.thoracic.org/index.php.