DONESTA safety study for menopause completes treatment phase and advances to data management & reporting phase - Seite 2

Graham Dixon, Chief Scientific Officer of Mithra, commented, “These projects highlight Mithra's commitment to demonstrate beneficial effects of E4 on other bothersome symptoms of menopause beyond VMS. The European study (C301) should reinforce the differentiated safety profile of E4, supporting further the broad therapeutic potential of this molecule. As Mithra manages its business challenges, the R&D team remains focused on supporting our estetrol platform to ensure that patients have access to our differentiated therapeutics. The advancements announced today showcase Mithra's resilience and determination in navigating the complex landscape of clinical research, further solidifying its position as a leader in Women's Health.”

For more information, please contact:

Mithra Pharmaceuticals SA Alex Sokolowski, PhD Head of IR & Communications [e-mail]                            [phone]

Frédérique Depraetere Communications Director [e-mail] [phone]

About Mithra
Mithra Pharmaceuticals SA (Euronext: MITRA) is a Belgian biopharmaceutical company dedicated to transforming women’s health by offering new choices through innovation, with a particular focus on contraception and menopause. Mithra’s goal is to develop products offering better efficacy, safety and convenience, meeting women’s needs throughout their life span. Mithra explores the potential of the unique native estrogen estetrol in a wide range of applications in women health and beyond. After having successfully launched the first estetrol-based product in 2021, the contraceptive pill ESTELLE, Mithra is now focusing on its second product DONESTA, the next-generation hormone therapy. Mithra also offers partners a complete spectrum of solutions from early drug development, clinical batches and commercial manufacturing of complex polymeric products (vaginal ring, implants) and complex liquid injectables and biologicals (vials, pre-filled syringes or cartridges) at its technological platform Mithra CDMO. Active in more than 100 countries around the world, is headquartered in Liège, Belgium. www.mithra.com