INmune Bio Reports Significant EEG Improvement in Alzheimer’s Patients Treated with XPro

Patients with Alzheimer’s Disease show improvement in brainwaves following 4 weeks of XPro therapy.

Boca Raton, Florida, March 05, 2024 (GLOBE NEWSWIRE) --  INmune Bio, Inc. (NASDAQ: INMB) (the “Company”), a clinical-stage immunology company targeting microglial activation and neuroinflammation as a cause of Alzheimer’s disease (AD) reports significant improvements in electroencephalography (EEG), a biomarker of brain function, in patients with moderate to severe Alzheimer’s Disease treated with XPro for four weeks.

Patients who received weekly XPro treatment for four weeks had a statistically significant increase in Alpha wave frequency and power (p<0.05). Reduced Alpha power is linked with cognitive decline and the progression of Alzheimer’s Disease. Alpha waves represent synchronized brain network activity that are essential for internal functions like mental arithmetic, short-term and working memory, and visual-spatial mental imagery exercises.  In individuals with AD, Alpha wave power is diminished due to the breakdown of brain networks associated with degeneration.

"Functional benefits are the true benchmark of a drugs biological efficacy, and these promising findings are part of a larger narrative that's still unfolding,” stated CJ Barnum, PhD, VP of Neuroscience at INmune Bio.  “We are committed to extensive research, drawing from our Phase 2 placebo-controlled trial to substantiate these findings.”

The seven patient pilot study in patients with moderate to severe AD sought to evaluate the utility of EEG as a functional biomarker of target engagement in evaluating the effects of XPro (XPro1595; pegipanermin), a next generation dominant-negative inhibitor of soluble TNF, in AD patients. These positive results support and add to the findings of the Phase 1 study in patients with AD that showed XPro treatment reduced biomarkers of inflammation and improved biomarkers of neurodegeneration, synaptic function and improved brain microstructure and promoted remyelination. The extent to which these biomarker changes impact cognition in patients with Early Alzheimer's Disease is currently being assessed in our ongoing randomized, placebo-controlled Phase 2 trial.