23andMe to Present Data on Two Clinical Stage Immuno-Oncology Programs at the American Association for Cancer Research (AACR) Annual Meeting 2024

• 23ME-01473, antibody targeting ULBP6: Data will be presented on the discovery and biology of ULBP6, and the potential to restore natural killer and T cell-mediated anti-tumor immunity by targeting ULBP6

• 23ME-00610, antibody targeting CD200R1: Preclinical data will be presented on targeting the CD200R1 pathway in T cells and natural killer cells using 23ME-00610 as a single agent, or in combination with other anti-tumor therapies
  

SAN DIEGO, April 05, 2024 (GLOBE NEWSWIRE) -- 23andMe Holding Co. (Nasdaq: ME) (“23andMe”), a leading human genetics and biopharmaceutical company, will present data on its two clinical stage programs, 23ME-01473 targeting ULBP6, and 23ME-00610 targeting CD200R1, at the American Association for Cancer Research (AACR) Annual Meeting 2024, taking place in San Diego, CA, April 5-10, 2024.

23ME-001473 (‘1473) - Clinical-Stage Dual Mechanism Monoclonal Antibody Targeting ULBP6

Key takeaways:

• 23andMe used its proprietary database of human genetic and health information to discover germline variants of ULBP6 associated with higher risks of immune disease and lower risks of cancer, suggesting the potential of ULBP6 as a novel immuno-oncology (I/O) drug target.
• Data also show soluble ULBP6 is a dominant immunosuppressor compared to other soluble NKG2D ligands due to its highest binding affinity to NKG2D among all NKG2D ligands.
• ‘1473 is a high affinity, Fc effector-enhanced, anti-ULBP6 antibody that restores the activation and tumor cell killing capacity of natural killer (NK) and T cells through the dual mechanisms of NKG2D and FcγRIIIa activation.
  

Key details:

• ULBP6 is a stress-induced ligand that is upregulated on the surface of cancer cells and binds to the activating immunoreceptor NKG2D found on NK and T cells.
• ULBP6 can be shed from the cell surface of tumor cells into a soluble form that acts as an immunosuppressive decoy to evade immune surveillance. Soluble ULBP6 is elevated in cancer patient plasma.
• Of all human NKG2D ligands, ULBP6 exhibits the highest binding affinity to NKG2D, which correlates with the high potency of soluble ULBP6 in suppressing PBMC-mediated interferon-gamma secretion and promoting tumor cell growth in vitro.
• Expression profiling of ULBP6 in various tumors using The Cancer Genome Atlas and immunohistochemistry reveals its elevated expression in squamous cell carcinomas and a subset of adenocarcinomas.
• ‘1473’s dual synergistic activation of NKG2D and FcγRIIIa leads to optimal activation of NK cells, which may reverse immune suppression and circumvent resistance to immune-checkpoint inhibitors due to the loss of neoantigen presentation in tumors.
• ‘1473 is currently being evaluated in a Phase I clinical trial for patients with advanced solid tumors (NCT06290388).

23ME-00610 - Clinical-Stage Monoclonal Antibody Targeting CD200R1