Antisoma´s phase III trial of AS1413 completes patient enrolment - Seite 2

this announcement are forward looking statements that are subject to a number of
risks and uncertainties that could cause actual results to differ materially
from results, performance or achievements expressed or implied by such
statements. These risks and uncertainties may be associated with product
discovery and development, including statements regarding the company´s clinical
development programmes, the expected timing of clinical trials and regulatory
filings. Such statements are based on management´s current expectations, but
actual results may differ materially.

About AS1413 (amonafide L-malate)
AS1413 (amonafide L-malate) was added to Antisoma´s pipeline through the
acquisition of Xanthus Pharmaceuticals, Inc. in June 2008. AS1413 is a novel DNA
intercalator that induces apoptotic signalling by blocking topoisomerase II
binding to DNA. This differs from the action of classical topoisomerase II
inhibitors, which induce apoptosis by causing extensive DNA damage. A further
distinctive feature of AS1413 is its ability to evade Pgp and related
transporters responsible for multi-drug resistance (MDR).

A pivotal phase III trial (ACCEDE) is evaluating AS1413 as a treatment for
secondary AML, a condition often associated with MDR and in which outcomes with
currently available treatments are poor. The trial was designed to screen 450
patients in order to enrol 420 eligible patients. Enrolment is now completed.
Data are expected in the first half of 2011 after all patients have completed
treatment under the trial protocol and findings have been collated and analysed.

An earlier phase II trial showed a complete remission rate of 39% in patients
with secondary AML, a finding that compares favourably with data from two
previous co-operative group studies in which similar patients were treated with
standard anthracycline plus cytarabine regimens.

Background on Antisoma
Antisoma is a London Stock Exchange-listed biopharmaceutical company that
develops novel products for the treatment of cancer. The Company has operations
in the U.K. and the U.S. Please visitwww.antisoma.com for further information
about Antisoma.

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Source: Antisoma plc via Thomson Reuters ONE

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