Clearside Biomedical Featured in Multiple Data Presentations at the 44th Virtual Annual Macula Society Meeting - Seite 3

CLS-TA (XIPERE) and Uveitic Macular Edema

Title: Post Hoc Analysis of Suprachoroidal CLS-TA versus Rescue Therapies for Uveitic Macular Edema: Safety and Visual Function

Lead Author: Eric Suhler, MD

Conclusions: Potential benefits of suprachoroidal delivery were explored in this analysis. CLS-TA is a proprietary suspension of the corticosteroid triamcinolone acetonide formulated for suprachoroidal administration in the treatment of macular edema associated with uveitis. In this post hoc analysis, unrescued CLS-TA subjects experienced statistically significant greater reduction in central subfield thickness (CST) and tended towards greater improvement in best corrected visual acuity (BCVA) compared with control subjects rescued with therapies reflecting current clinical treatment. Suprachoroidally administered CLS-TA also appeared to be associated with a lower incidence of intraocular pressure (IOP)-related safety findings. This post hoc analysis provides a comparison of CLS-TA to a “real world” mix of rescue treatments, and corroborates the pre-specified endpoints of the Phase 3 PEACHTREE study.

Title: Systemic Therapy and Efficacy of CLS-TA: Results from the Phase 3 PEACHTREE Clinical Trial

Lead Author: Phoebe Lin, MD, PhD

Conclusions: This analysis explored the potential impact of systemic immunomodulatory therapy on outcomes for CLS-TA treatment of uveitic macular edema. For this post hoc analysis, subjects were classified into two groups: those who did or did not receive systemic immunomodulatory therapy during the baseline visit. The benefit of suprachoroidally injected CLS-TA versus the control in treating macular edema associated with non-infectious uveitis was noted regardless of administration of systemic therapy at baseline, and these results corroborate the prespecified study analyses in PEACHTREE.

Title: OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema

Lead Author: Dilraj S. Grewal, MD

Conclusions: There is limited information on longitudinal structure-functional correlations in uveitic macular edema. In clinical practice, physicians often base treatment decisions on both BCVA and optical coherence tomography (OCT) assessment.  This study assessed these relationships, focusing on baseline anatomic features with potential prognostic value for visual response in a post hoc analysis of 198 eyes with non-infectious uveitis. The analysis showed clinically relevant relationships between BCVA and OCT anatomic and temporal features. Anatomic response may precede visual response in uveitic macular edema.