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Abivax publishes data of ABX464 induction and long-term maintenance phase 2a ulcerative colitis study in the prestigious journal 'Gastroenterology' - Seite 2

Prof. Séverine Vermeire, M.D., Ph.D., Head of the IBD Center at the University Hospitals Leuven, Belgium, principal investigator of the study and first author of the publication, added: "As principal investigator I am pleased to see that the scientific community confirmed the safety and durability of clinical efficacy of the phase 2a induction and long-term study results conducted with ABX464 in ulcerative colitis patients. I am now impatient to see the outcome of the phase 2b induction study and the subsequent maintenance trial to confirm these positive observations in a larger set of patients."

At the end of the eight-week induction of the phase 2a proof-of-concept clinical study in ulcerative colitis, 35% and 70% of patients in the ABX464 active group achieved clinical remission and clinical response versus 11.1% and 33.3% in the placebo group, respectively. Endoscopic improvement and remission were observed in 50% and 10% of patients receiving ABX464, respectively, versus 11.1% each for placebo.

To date, 15 patients in the phase 2a maintenance study are still on continued daily treatment and a total of 800 patients across different indications have so far been treated with ABX464.

ABX464 is currently being evaluated in a phase 2b UC clinical trial, a phase 2b/3 Covid-19 clinical trial and a phase 2a rheumatoid arthritis clinical trial. The initiation of a phase 2b/3 Crohn's disease clinical trial as well as a phase 3 clinical program in ulcerative colitis are planned, subject to the results of the phase 2b clinical trial in UC.

About Abivax (www.abivax.com)

Abivax, a clinical stage biotechnology company, is modulating the body's natural immune machinery to treat patients with chronic inflammatory diseases, viral infections, and cancer. Abivax is listed on Euronext compartment B (ISIN: FR0012333284 - Mnémo: ABVX). Based in Paris and Montpellier, Abivax has two drug candidates in clinical development, ABX464 to treat severe inflammatory diseases, and ABX196 to treat hepatocellular carcinoma. More information on the company is available at www.abivax.com. Follow us on Twitter @ABIVAX_.