Celyad Oncology Presents Preliminary Data from Phase 1 IMMUNICY-1 Trial of shRNA-based Allogeneic CAR T Candidate CYAD-211 in Relapsed/Refractory Multiple Myeloma at the European Hematology Association Virtual Congress - Seite 2
Of the six patients dosed at the first two dose levels (30×106 and 100×106 cells per infusion):
- No dose limiting toxicity (DLT), Graft-versus Host disease (GvHD) or CAR T-cell-related encephalopathy syndrome (CRES) were observed in the first two dose cohorts.
- One cytokine release syndrome (CRS) Grade 1 (fever) requiring hospitalization occurred 10 days post CYAD-211 administration in patient 1 (dose level 1) who achieved a partial response (PR).
- One patient experienced an anemia adverse event (Grade 3) and neutropenia (Grade 4) possibly related to CYAD-211.
Clinical activity:
Of the five evaluable patients at the first two dose levels (30×106 and 100×106 cells per infusion):
- Two patients achieved a PR. Both patients were ‘triple-therapy exposed’ (previously treated with an immunomodulator (IMiD), a proteasome inhibitor and an anti-CD38 antibody).
- The three additional patients had stable disease (SD).
Cell kinetics:
- CYAD-211 cells were detected by PCR-based methods in all six patients from dose cohorts 1 and 2.
- Cell engraftment was seen in all three patients at dose level 2 at a similar magnitude. In addition, preliminary data suggest that all patients in dose level 2 showed deep lymphodepletion. Across dose level 1, the depth of lymphodepletion appears to correlate with the degree of observed systemic CAR T engraftment.
Next steps:
- Enrollment in dose cohort 3 (300×106 cells per infusion) is ongoing.
- Additional clinical data from the dose escalation trial are expected during second half 2021.
- shRNA technology platform to be highlighted at upcoming virtual R&D Day in Q3 2021.
Conference Call and Webcast Details
Celyad Oncology will host a conference call to discuss the update from EHA on Friday, June 11, 2021 at 2 p.m. CET / 8 a.m. ET. The conference call can be accessed through the following numbers:
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United States: #1 877-407-9208
International: #1 201-493-6784
The conference call will be webcast live and can be accessed here. The event will also be archived and available on the “Events ” section of the company’s website. Please visit the website several minutes prior to the start of the broadcast to ensure adequate time for registration to the webcast.
About CYAD-211
CYAD-211 is an investigational, shRNA-based allogeneic CAR T candidate for the treatment of r/r MM. CYAD-211 is engineered to co-express an anti-BCMA targeting chimeric antigen receptor and a single shRNA to knockdown the CD3ζ component of the T cell receptor complex.