Baxter Presents Critical Care Data at 34th Annual European Society of Intensive Care Medicine LIVES Congress - Seite 2

Baxter and bioMérieux previously announced an agreement to develop and distribute a test to measure the CCL14 biomarker to help improve identification of and personalize treatment for patients at risk of PS-AKI.

Fluid Responsiveness and Creatinine Increase in Patients with Septic Shock (Abstract #000338)

This Baxter-sponsored sub-analysis of the FRESH clinical trial patient population compared patients’ true baseline creatinine levels (prior to hospitalization) to creatinine levels over the course of hospitalization. The findings demonstrated that analyzing patient creatinine levels and fluid responsiveness may help preserve kidney function and decrease the risk of AKI in the septic patient population. Patients with septic shock may be vulnerable to conditions like AKI, and high creatinine levels may indicate that the kidneys are not working properly. Study investigators evaluated 83 patients randomized to the intervention arm who were assessed for fluid responsiveness using Baxter’s Starling Fluid Management Monitoring System before further treatment was administered, and 41 patients randomized to the control arm who received usual care. Patients in the intervention arm received less fluid over a 72-hour period (3354.2 ± 2179.6) compared to the control arm (4721.3 ± 3319.1, p=0.007). Patients in the intervention arm displayed a statistically significant decrease in the need for renal replacement therapy (RRT) to remove fluid and toxins (5.1% vs 17.5%, p= 0.04). Additionally, this sub-analysis showed that 25.9% of patients in the intervention arm exhibited a two-fold increase in creatinine over their true baseline levels, compared to 48% of patients in the control arm (p=0.04).

Additionally, Baxter presented an abstract at ESICM titled “Fluid Responsiveness and Vasopressor Use in Patients with Septic Shock” (Abstract #000340), that further evaluated the administration of vasopressors (drugs used to constrict the blood vessels and raise blood pressure) in the FRESH patient population. The findings suggest that administering fluid only when it is effective at improving perfusion (the passage of fluids through the blood vessels) may lead to improved patient outcomes and does not increase the need for vasopressors and time on treatment.