Reflecting on Research in Genitourinary Cancers - Seite 2

One area where we're trying to establish new standards of care is across specific patient populations. For some GU cancers, there aren't known, specific genomic targets or biomarkers of relevance, which presents a challenge for physicians trying to tailor treatments to each individual patient. So, that's an area where we can continue to improve to meet the needs of even more patients. Currently, treatments are mostly being used broadly across patient segments. It's important to continue to collaborate and conduct translational research to establish the best treatments for each segment to improve outcomes for all patients.

Q: What options are being explored in metastatic stages of these diseases? How about in earlier stages?

Dr. Walker: In the metastatic setting, we're continuing to find new modalities that are relevant across GU malignancies. We've come a long way with treatments such as immunotherapies and targeted agents. The most interesting question being asked in research now is: how we can we combine these? Exploring combination approaches can help us find ways to serve patients who are still facing high unmet needs. While the scientific community has significantly increased long-term survival benefits in this field and have achieved longer, durable responses, we still have patients who don't respond. Combining these proven agents and partnering to find new drugs that may work here is crucial.

The same applies in the earlier stages of disease. We've done a lot of great research in the metastatic setting and now we're evaluating how we can apply those learnings to the earlier stages of the disease and testing whether these mechanisms work there. We've already seen tremendous developments, especially in kidney and bladder cancers, over the last several years, specifically with immunotherapy in earlier treatment settings. It's truly transformative work.

Q: What do upcoming data to be presented at ASCO GU 2023 mean for patients with GU cancers?

Dr. Walker: I think ASCO GU is going to be very exciting and insightful this year. I'm expecting to see a lot of groundbreaking data. We're excited to see long-term follow-up data across kidney, bladder and prostate cancers - not only with our own research but across the field. We have some great data and we're looking forward to seeing what others have to share, as well.

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