Nymox December 27 Message to Shareholders - Seite 2

The second major indication is for low grade prostate cancer. We have been very busy on this extraordinary advancement. and we hope to have more news for our supporters during Q1 or Q2 of 2024. There is an important potential place for Nymozarfex for low grade prostate cancer. Most men start out with a low grade cancer, and there is a need for a safe and effective initial treatment before the disease advances to where invasive interventions become necessary.  Again, individuals with experience with this common clinical condition will be interested in this potentially major step forward.

Prostate cancer is the most common non-skin cancer in men. Approximately 1 in 8 men will develop prostate cancer.

Our clean-up of management in 2023 was a much-needed improvement, and we are delighted to have had the essentially unanimous support of shareholders in the termination of employees and agents who were involved in extreme and underhanded malfeasance, which we have already communicated. There is litigation involved and when there is material news as always, we will provide it in a timely manner.
The normal Annual General Meeting will occur in the near future after a temporary delay.

About NYMOX

Nymox is in the process of submitting applications for the approval to market the Company's first in class drug NYMOZARFEX (TM) to treat the symptoms of benign prostatic hyperplasia (BPH). BPH is one of the most common conditions affecting middle aged and elderly men throughout the world. BPH can be devastating to men who suffer from the condition. Current treatments are associated with numerous intolerable side effects including sexual problems, such as impotence and retrograde ejaculation. Medications for BPH have been associated with prostate cancer, depression, gynecomastia and other adverse effects. The majority of men stop taking the available medications due to these and other problems. Surgery is often needed for advanced BPH. Surgery is usually effective but it is not without risks, the discomforts of surgery, and BPH surgery has side effects such as permanent retrograde ejaculation for many patients.

Nymox recently reported 10-year follow-up new data on all available patients from its U.S. clinical trial of NYMOZARFEX (TM) for the treatment of low grade localized prostate cancer. The available long-term data newly assessed, confirmed that all available data shows that the NYMOZARFEX (TM) treatment had important and statistically significant benefit for reducing the long-term progression of these prostate cancers.