PAVmed Adds EsoCure Esophageal Ablation Device with Patented Caldus Technology to Commercial Product Pipeline

Disposable single-use device designed to provide safer, more efficient and cost-effective ablation of dysplastic Barrett’s Esophagus, complementing Lucid Diagnostics’ EsoGuard and EsoCheck products

NEW YORK, Feb. 18, 2020 (GLOBE NEWSWIRE) -- PAVmed Inc. (Nasdaq: PAVM, PAVMZ) (the “Company” or “PAVmed”), a highly differentiated, multiproduct medical device company, today announced it has added the EsoCure Esophageal Ablation Device with Caldus Technology to its commercial product pipeline.

EsoCure’s disposable single-use thermal balloon ablation catheter is designed to advance through the working channel of a standard endoscope and allow the clinician to treat dysplastic Barrett’s Esophagus (BE) before it can progress to highly lethal esophageal cancer (EAC) and to do so without the need for complex and expensive capital equipment. It complements Lucid Diagnostics’ (“Lucid”) portfolio of EsoGuard and EsoCheck products, which are designed to detect nondysplastic and dysplastic BE, as well as EAC itself.

EsoCure incorporates PAVmed’s patented Caldus Technology (“Caldus”) which allows direct thermal tissue ablation using disposable single-use ablation devices. Devices which incorporate Caldus use a proprietary heating and infusion system built into the device handle to continuously circulate heated fluid through a proprietary multi-lumen balloon catheter, while maintaining constant balloon volume, pressure and tissue contact. The balloon ablates and destroys the cells of the targeted region by directly heating them above their cytotoxic threshold for a specified period of time. EsoCure consists of a device handle with a fluid cartridge, heating, infusion and control mechanisms; a multi-lumen catheter which passes through the working channel of the endoscope; and, a proprietary distal balloon which directly delivers thermal ablation energy to the esophagus.

“I am excited to add EsoCure to PAVmed’s expanding commercial product pipeline,” said Lishan Aklog, M.D., PAVmed’s Chairman and Chief Executive Officer. “EsoCure is a major addition to our product portfolio, with a substantial market opportunity and strong synergies to Lucid’s EsoGuard and EsoCheck products. Once commercialized, PAVmed and Lucid will be able to offer the only comprehensive panel of products capable of detecting and treating conditions across the spectrum of conditions from Barrett’s Esophagus to esophageal cancer. With our progress to date we expect to complete development and FDA 510(k) submission of EsoCure by early 2021, if not earlier.