Feasibility Arrangement for shelf-stable powder form of messenger RNA COVID-19 Vaccine Candidate announced by GreenLight Biosciences and TFF Pharmaceuticals - Seite 2

Should the feasibility study prove successful, a further stage of work will include non-needle administration methods for the GreenLight mRNA vaccine candidate  in a dry powder form that could be administered via nasal spray or lung inhalation.

Under the Feasibility Agreement, GreenLight Biosciences is delivering its COVID-19 messenger RNA product candidate materials to TFF in order to perform feasibility formulation work and testing.

The goal of this feasibility work is to formulate and identify an optimal formulation of the GreenLight Biosciences messenger RNA product candidate in a dry powder form, which has superior stability, maintains particle size of the encapsulated messenger RNA as well as high encapsulation efficiency and has rapid reconstitution characteristics for injection.

If successful, this should make messenger RNA vaccines available to the whole world simplifying cold chain supply challenges. Thin film technology potentially allows vaccines to be transported at fridge, or even room, temperatures as a powder. It can then be reconstituted by a health care worker at the point of use.

This agreement is part of GreenLight Biosciences goal of using its unique manufacturing platform to produce vaccines in volumes that can serve the world's need for billions of doses. This partnership offers the hope of speeding these doses into use.

"Overcoming the COVID-19 pandemic requires a large volume of second generation vaccines that adapt rapidly and can be delivered to all parts of the world, regardless of local cold chain infrastructure," said Andrey J. Zarur, Ph.D, CEO of GreenLight Biosciences. "Thin Film Freezing has the potential to deliver on this promise by reformulating the complex messenger RNA molecules of our vaccine candidate into a shelf-stable powder readily reconstituted by a healthcare worker just prior to injection."

TFF has two candidates in phase one clinical trials, Voriconazole Inhalation Powder and Tac-Lac Inhalation Powder. TFF requires about six weeks from receipt of materials to prepare an initial dry powder form of GreenLight's vaccine candidate to test for reconstitutability and viability.

About GreenLight Biosciences, Inc.
GreenLight Biosciences has several messenger RNA Covid vaccine candidates in development,  are built off of GreenLight's manufacturing platform, which delivers high-quality RNA at a lower cost and higher speed than comparable processes.