New Analysis Highlights Importance of Adhering to Uninterrupted Full Course of Treatment with TEPEZZA (teprotumumab-trbw) to Support Thyroid Eye Disease (TED) Patient Outcomes - Seite 2

Horizon also announced further results from the TEPEZZA Phase 4 clinical trial in TED patients with long disease duration and low CAS. Findings reinforced a meaningful reduction of proptosis at Week 24 for all subgroups (≥2mm) with comparable improvements regardless of magnitude of baseline proptosis levels (<=25 vs >25mm). Smokers treated with TEPEZZA had a change from baseline (CFB) of -2.83 mm (vs 0.00 CFB for placebo); treated non-smokers had a -2.39 mm CFB (vs -1.00 mm for placebo). Males treated with TEPEZZA (n=10) had a CFB of -2.20 mm (vs -1.00 for placebo, n=2), and in treated females (n=29), CFB was -2.55 mm (vs -0.89 for placebo, n=18).³

Additionally, research on the impact of TED on patients’ QOL was presented at ATA 2023, assessing how characteristics like sex, age and severity of symptoms affect visual functioning and appearance as measured by the Graves’ Ophthalmopathy Quality of Life (GO-QOL) questionnaire. The analysis looked at baseline GO-QOL data for 171 moderate-to-severe TED patients prior to treatment in two clinical trials. Visual functioning results showed that the majority of participants reported limitations in important daily activities like reading (74%) or driving (64%), and nearly all (95%) were affected by the changes in their appearance. Certain sub-populations noted more significant impact on their daily activities, including those with severe diplopia (n=74) and patients with more proptosis (n=104).⁴

“We are committed to fully understanding the daily challenges that patients with Thyroid Eye Disease experience regardless of their disease activity or duration, including things like symptoms that limit the ability to drive at night, or the mental toll that a lack of independence may bring,” said Beth Scott, OD, MS, vice president, medical affairs, Horizon. “The data presented this weekend help us further our mission of ensuring those in the Thyroid Eye Disease community receive appropriate care.”

About Thyroid Eye Disease (TED)

TED is a serious, progressive, debilitating and potentially vision-threatening rare autoimmune disease.¹ TED often occurs in people living with Graves’ disease, but is a distinct disease that is caused by autoantibodies activating an IGF-1R-mediated signaling complex on cells within the retro-orbital space.^5,6 This leads to a cascade of negative effects, which may cause long-term, irreversible damage, including blindness. Early signs and symptoms of TED may include dry eyes and grittiness; redness, swelling and excessive tearing; eyelid retraction; proptosis; pressure and/or pain behind the eyes; and diplopia.^7,8