TFF Pharmaceuticals and Leidos to Advance Next-Generation Biodefense Countermeasures Under the DARPA PPB Program into Preclinical Testing

The Leidos team’s Next-Generation Medical Countermeasures (MCMs) Successfully Formulated with Company’s Proprietary Thin Film Freezing Technology

MCM Candidates Demonstrated Chemical and Biological (CB) Neutralizing Activity in Well-Validated In Vitro and Ex Vivo Models

FORT WORTH, Texas, May 23, 2024 (GLOBE NEWSWIRE) -- TFF Pharmaceuticals, Inc. (NASDAQ: TFFP) (“the Company”), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented Thin Film Freezing (TFF) technology platform, today announced that the government will be advancing several next-generation medical countermeasures (MCMs) formulated with its Thin Film Freezing technology into advanced preclinical testing. TFF Pharmaceuticals is collaborating with Leidos, a leading Fortune 500 information technology, engineering and science solutions and services leader, to develop next-generation MCMs designed to protect military and healthcare personnel against future chemical and biological (CB) threats. The research is funded by the Defense Advanced Research Projects Agency (DARPA) under a contract through the Personalized Protective Biosystems (PPB) program.

Program Update

The candidate MCMs delivered by Leidos to TFF Pharmaceuticals have been successfully formulated utilizing the Company’s proprietary Thin Film Freezing technology platform. Formulated materials have demonstrated neutralizing activity in well-validated in vitro models. The MCMs are now progressing into in vivo preclinical testing, which will be conducted at DARPA-contracted laboratories.

“Over the last several months, we have made significant progress working with Leidos to develop innovative new medical countermeasures utilizing our Thin Film Freezing technology,” said Dr. Harlan Weisman, Chief Executive Officer of TFF Pharmaceuticals. “The ultimate goal of this research collaboration is to develop products that protect the lives of our military personnel and first responders, and our Thin Film Freezing technology is once again demonstrating its versatility by addressing a uniquely challenging problem in biodefense drug development. In the months ahead, we hope to demonstrate that MCMs formulated with Thin Film Freezing can neutralize biochemical threats in vivo directly at the site of entry. We also expect that our formulation technology will enable these countermeasures to be developed as needle-free and temperature independent products, which could dramatically improve storage and deployment capabilities in the face of urgent future biochemical threats.”