Was zum Teufel ist mit Vertex Los???? - 500 Beiträge pro Seite
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ISIN: US92532F1003 · WKN: 882807 · Symbol: VX1
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Letzter Kurs 10.05.24 Tradegate
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Vertex Pharmaceuticals Aktien ab 5,80 Euro handeln - Ohne versteckte Kosten!Anzeige |
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Hallo Ihr Aktienfreier!!
Kann mir mal einer von Euch kalten Puffern erklären was zur Zeit mit Vertex los ist.
Bin grade nicht in Vertex drin; habe es aber vor und zwar mit Optionsscheinen. Voll der Hebel.
Könnte ein momentaner Einstieg mein schwer verdientes Ludengeld unter Umständen atomisieren???????????
Um Antwort wird gebeten
Der Lude
Kann mir mal einer von Euch kalten Puffern erklären was zur Zeit mit Vertex los ist.
Bin grade nicht in Vertex drin; habe es aber vor und zwar mit Optionsscheinen. Voll der Hebel.
Könnte ein momentaner Einstieg mein schwer verdientes Ludengeld unter Umständen atomisieren???????????
Um Antwort wird gebeten
Der Lude
Ein halbes Jahr nach der Natrecor-Zulassung reklamieren die Kalifornier
beispielsweise selbstbewusst die Pole-Position im Rennen um einen
Blocker gegen das Entzündungsenzym p38 Kinase. Um diese potenzielle
neue Standardtherapie gegen Arthritis - und vermutlich zahlreiche weitere
Krankheiten - balgt sich die halbe Branche, Giganten wie Johnson &
Johnson (JNJ) inklusive.
"Das ist ein verdammt enges Rennen", kommentiert Scios-Manager David
Gryska, "und wir haben nicht vor Zweiter zu werden." Rivale Vertex
(VRTX) ist eben rausgeflogen, weil sein Enzym-Blocker im Tierversuch
bei hoher Dosierung Vergiftungen auslöste. Dieser Flop zeigt die Risiken
des neuesten Scios-Abenteuers. Realistische Schätzungen des
Marktvolumens von einer Milliarde Dollar und mehr markieren dagegen
die Chancen.
Natrecor-Partner Glaxo, einer der weltweit kapitalkräftigsten
Pharmakonzerne, arbeitet selbst mit eher mäßigem Erfolg an einem
Arthritis-Medikament der neuen Generation. Zur Vorstellung, dass die
Briten auch hier mit Scios ins Geschäft kommen könnten, nachdem für den
Scios-Blocker bereits die ersten vielversprechenden Testergebnisse
vorliegen, braucht es nicht viel Fantasie.
beispielsweise selbstbewusst die Pole-Position im Rennen um einen
Blocker gegen das Entzündungsenzym p38 Kinase. Um diese potenzielle
neue Standardtherapie gegen Arthritis - und vermutlich zahlreiche weitere
Krankheiten - balgt sich die halbe Branche, Giganten wie Johnson &
Johnson (JNJ) inklusive.
"Das ist ein verdammt enges Rennen", kommentiert Scios-Manager David
Gryska, "und wir haben nicht vor Zweiter zu werden." Rivale Vertex
(VRTX) ist eben rausgeflogen, weil sein Enzym-Blocker im Tierversuch
bei hoher Dosierung Vergiftungen auslöste. Dieser Flop zeigt die Risiken
des neuesten Scios-Abenteuers. Realistische Schätzungen des
Marktvolumens von einer Milliarde Dollar und mehr markieren dagegen
die Chancen.
Natrecor-Partner Glaxo, einer der weltweit kapitalkräftigsten
Pharmakonzerne, arbeitet selbst mit eher mäßigem Erfolg an einem
Arthritis-Medikament der neuen Generation. Zur Vorstellung, dass die
Briten auch hier mit Scios ins Geschäft kommen könnten, nachdem für den
Scios-Blocker bereits die ersten vielversprechenden Testergebnisse
vorliegen, braucht es nicht viel Fantasie.
@alle,
weis jemand, warum Vertex Heute so volatil ist?
Zuerst von 15 auf 17, dann wieder auf 16 zurück.
Vielleicht die Zahlen, die am 18. kommen sollen?
Lange nichts mehr gehört von Vertex Freunden.
Bitte um Antworten, Danke.
mfg nino
weis jemand, warum Vertex Heute so volatil ist?
Zuerst von 15 auf 17, dann wieder auf 16 zurück.
Vielleicht die Zahlen, die am 18. kommen sollen?
Lange nichts mehr gehört von Vertex Freunden.
Bitte um Antworten, Danke.
mfg nino
@ Der Lude
DU SPRUCHFREIER
DU SPRUCHFREIER
@all
Das Biotechunternehmen Vertex Pharmaceuticals lag mit dem erzielten Verlust von 28 Cents/Aktie im Q2 im Rahmen der Analystenschätzungen. Der Umsatz stieg um 4,2% auf 42,3 Mio $ gegenüber den erwarteten 45,3 Mio $. Für das laufende Geschäftsjahr sehe man einen Umsatz von 180-195 Mio $ voraus, Analysten sehen diesen bei 187 Mio $.
© BörseGo
Das Biotechunternehmen Vertex Pharmaceuticals lag mit dem erzielten Verlust von 28 Cents/Aktie im Q2 im Rahmen der Analystenschätzungen. Der Umsatz stieg um 4,2% auf 42,3 Mio $ gegenüber den erwarteten 45,3 Mio $. Für das laufende Geschäftsjahr sehe man einen Umsatz von 180-195 Mio $ voraus, Analysten sehen diesen bei 187 Mio $.
© BörseGo
moin moin
zurück lehnen
etwas gedud
und den kurs genißen
mfg
zurück lehnen
etwas gedud
und den kurs genißen
mfg
Was denkst Du, wohin geht der Kurs - sagen wir - bis Ende 2003?
Nu kommt Ihr kalten Freier,
das kann doch nicht alles sein was es neues über Vertex gibt.
Brauch jede Mark vor Weihnachten.
das kann doch nicht alles sein was es neues über Vertex gibt.
Brauch jede Mark vor Weihnachten.
@Der Lude
Brauch jede Mark vor Weihnachten.
Dann hast Du Deinen Beruf verfehlt.
tanka
Brauch jede Mark vor Weihnachten.
Dann hast Du Deinen Beruf verfehlt.
tanka
Nasdaq Life Sciences Forum Webcast Monday, September 16, 8.30 a.m. - 12.30 p.m. GMT
Wednesday September 4, 9:26 am ET
LONDON--(BUSINESS WIRE)--Sept. 4, 2002--The Nasdaq Stock Market is hosting its 6th Life Sciences Forum with presentations from the following companies: Affymetrix, Inc. (NASDAQ:AFFX - News), Genzyme General (NASDAQ:GENZ - News) Pharmaceutical Product Development, Inc. (NASDAQ:PPDI - News), Sepracor Inc. (NASDAQ:SEPR - News), Vertex Parmaceuticals, Inc. (NASDAQ:VRTX - News). The Nasdaq Life Sciences Forum web cast will take place on Monday, September 16 between 08:30 a.m. - 12:30 p.m. GMT. All company audio-webcasts and video-interviews can be accessed at www.nasdaq.com (Listed Companies - Investor Conference Webcasts), directly at
Wednesday September 4, 9:26 am ET
LONDON--(BUSINESS WIRE)--Sept. 4, 2002--The Nasdaq Stock Market is hosting its 6th Life Sciences Forum with presentations from the following companies: Affymetrix, Inc. (NASDAQ:AFFX - News), Genzyme General (NASDAQ:GENZ - News) Pharmaceutical Product Development, Inc. (NASDAQ:PPDI - News), Sepracor Inc. (NASDAQ:SEPR - News), Vertex Parmaceuticals, Inc. (NASDAQ:VRTX - News). The Nasdaq Life Sciences Forum web cast will take place on Monday, September 16 between 08:30 a.m. - 12:30 p.m. GMT. All company audio-webcasts and video-interviews can be accessed at www.nasdaq.com (Listed Companies - Investor Conference Webcasts), directly at
moin moin
ich sehe eine millenieum einstellig wwerden
eine medarex gehjt den bach runter
und so weiter
Vertex steht doch eigentlich gut dar
hat bestimmt einen grund
mfg
ich sehe eine millenieum einstellig wwerden
eine medarex gehjt den bach runter
und so weiter
Vertex steht doch eigentlich gut dar
hat bestimmt einen grund
mfg
yep
ich bin short, und ich liebe kampf,
sind dem luden, die pferdchen abhanden gekommen,
er hätte weiterhin in osteuropa und asien investieren sollen,
nicht in vertex,
geht zeit, geht rolex
ich bin short, und ich liebe kampf,
sind dem luden, die pferdchen abhanden gekommen,
er hätte weiterhin in osteuropa und asien investieren sollen,
nicht in vertex,
geht zeit, geht rolex
@all
schöne Nachricht.
Phase III, 24-Week Results for the NEAT Trial Comparing GW433908 (908) to Nelfinavir: Presented At ICAAC
Friday September 27, 2:00 pm ET
SAN DIEGO, Sept. 27 /PRNewswire-FirstCall/-- Results of the NEAT trial, an open-label, multi-center study evaluating the safety and efficacy of the investigational protease inhibitor (PI) GW433908 (908) in antiretroviral therapy-naive patients versus nelfinavir (NFV, Viracept®), were presented here today at the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). In the trial, 73 percent of 166 HIV+ patients achieved undetectable viral load with the investigational protease inhibitor 908, compared to 54 percent of 83 patients taking nelfinavir. The 908 compound was co-discovered by GlaxoSmithKline (GSK) and Vertex Pharmaceuticals (Nasdaq: VRTX - News). Once approved, 908 will be marketed by GSK and co-promoted by Vertex Pharmaceuticals.
ADVERTISEMENT
The results come from a 24-week interim analysis of the NEAT study in which patients were randomized to receive either 1400 mg of 908 (2 tablets twice a day) or 1250 mg of NFV (5 tablets twice a day). Both groups took the medications in combination with 300 mg twice a day (BID) of abacavir (ABC) and 150 mg BID of lamivudine (3TC). ABC and 3TC are nucleoside analogue reverse transcriptase inhibitors (NRTIs).
"Although the results are from only the first 24 weeks of this study, we think the Phase III data on the safety and efficacy of the investigational agent 908 as a therapy for HIV infection are important," said Doug Manion, M.D., vice president of clinical development, GSK.
Efficacy Results from NEAT
"At 24 weeks, 73 percent of 166 HIV-positive patients taking 908 achieved undetectable viral loads [<400copies/mL] compared to 54 percent of 83 patients taking nelfinavir," said Jeffrey P. Nadler, M.D., University of South Florida College of Medicine, Tampa, who presented the data at ICAAC. Further, 54 percent of patients in the 908 arm achieved a viral load less than 50 copies/mL, compared to 40 percent of patients taking nelfinavir.
Among people with a high viral load (>100,000 copies/mL) taking 908, 71 percent achieved a viral load <400 copies/mL and 42 percent achieved viral load <50 copies mL, versus 35 percent and 11 percent, respectively, of patients with high viral loads taking NFV, according to Dr. Nadler. Among patients with a viral load less than 100,000 copies/mL at baseline, 74 percent of patients in the 908 arm achieved an undetectable viral load, compared to 70 percent of patients in the nelfinavir arm.
Safety Results from NEAT
The incidence of dose limiting adverse events (AEs) and severe laboratory abnormalities was low in both groups. The only AE that was significantly different between the two groups was diarrhea, which was significantly more prevalent in patients on NFV (17 percent) than patients on 908 (5 percent). Most common AEs with 908 were allergy (8 percent), rash (8 percent) and nausea (5 percent).
"While the overall rates of discontinuations were similar in both study groups, more subjects withdrew due to insufficient viral response in the NFV group (11 percent) compared to the 908 group (2 percent)," said Dr. Nadler.
NEAT Study Demographics
The study population included:
A large proportion of patients with advanced HIV disease. Nearly 50
percent had viral loads greater than 100,000 copies at baseline, and
approximately 50 percent had CD4+ counts <200 cells/mm3, a criterion
that meets the definition of AIDS established by the Centers for
Disease Control and Prevention (CDC). Median CD4+ cell count was 214.
Further, approximately 20 percent had experienced a CDC Class C event
characteristic of advanced disease.
Gender diversity, with females representing 31 percent of the patient population.
Ethnic diversity, including a high proportion of Hispanic patients (44 percent) and patients of African descent (31 percent).
The investigational PI 908 is the calcium phosphate ester pro-drug of amprenavir. In the study reported at ICAAC, patients in the 908 group took 2 pills BID compared to 5 pills BID in the NFV group. It is being studied in several dosing presentations: twice a day (BID), once a day (QD) in combination with the PI-booster ritonavir, and twice a day (BID) with ritonavir. In the NEAT study, 908 was taken without food or fluid restrictions, while patients are advised to take nelfinavir with food.
Ongoing Clinical Trials with 908
NEAT, the first of three pivotal trials to support regulatory approval of 908, is a Phase III, randomized, open-label, parallel-group, 48-week study. The primary endpoint is the proportion of subjects with vRNA <400 c/mL at 24 and 48 weeks. More than 1,100 people are participating in Phase III trials to test the safety and efficacy of 908. In addition to the NEAT study, two other large-scale clinical trials of 908 are under way. The SOLO study is an open- label trial that has enrolled more than 650 HIV positive, treatment-naive patients. Participants have been randomized to receive either 1400 mg of 908 plus 200 mg ritonavir QD or 1250 mg of nelfinavir BID. All also receive ABC and 3TC, two nucleoside reverse transcriptase inhibitors. The trial is being conducted at more than 50 research centers worldwide and is designed to assess the safety and efficacy of each regimen over a period of 48 weeks. Results from the SOLO trial are expected to be presented at an upcoming medical conference.
The CONTEXT study is an open-label trial in PI-experienced subjects assessing 908 dosed at 700 mg BID in combination with 100 mg ritonavir, or 908 at 1400 mg QD in combination with 200 mg ritonavir, compared to a third treatment arm of 400 mg lopinavir/100 mg ritonavir BID. Participants also receive two nucleoside reverse transcriptase inhibitors. The trial is fully enrolled with more than 300 patients and is being conducted at more than 80 research centers worldwide. The study is assessing the safety and efficacy of each regimen at 24 and 48 weeks. Results from the CONTEXT trial are expected to be presented in 2003.
GlaxoSmithKline is one of the world`s leading research-based pharmaceutical and healthcare companies and an industry leader in HIV research and therapies. The company is engaged in basic research programs designed to investigate new targets to treat HIV.
Grüße
Skaya
schöne Nachricht.
Phase III, 24-Week Results for the NEAT Trial Comparing GW433908 (908) to Nelfinavir: Presented At ICAAC
Friday September 27, 2:00 pm ET
SAN DIEGO, Sept. 27 /PRNewswire-FirstCall/-- Results of the NEAT trial, an open-label, multi-center study evaluating the safety and efficacy of the investigational protease inhibitor (PI) GW433908 (908) in antiretroviral therapy-naive patients versus nelfinavir (NFV, Viracept®), were presented here today at the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). In the trial, 73 percent of 166 HIV+ patients achieved undetectable viral load with the investigational protease inhibitor 908, compared to 54 percent of 83 patients taking nelfinavir. The 908 compound was co-discovered by GlaxoSmithKline (GSK) and Vertex Pharmaceuticals (Nasdaq: VRTX - News). Once approved, 908 will be marketed by GSK and co-promoted by Vertex Pharmaceuticals.
ADVERTISEMENT
The results come from a 24-week interim analysis of the NEAT study in which patients were randomized to receive either 1400 mg of 908 (2 tablets twice a day) or 1250 mg of NFV (5 tablets twice a day). Both groups took the medications in combination with 300 mg twice a day (BID) of abacavir (ABC) and 150 mg BID of lamivudine (3TC). ABC and 3TC are nucleoside analogue reverse transcriptase inhibitors (NRTIs).
"Although the results are from only the first 24 weeks of this study, we think the Phase III data on the safety and efficacy of the investigational agent 908 as a therapy for HIV infection are important," said Doug Manion, M.D., vice president of clinical development, GSK.
Efficacy Results from NEAT
"At 24 weeks, 73 percent of 166 HIV-positive patients taking 908 achieved undetectable viral loads [<400copies/mL] compared to 54 percent of 83 patients taking nelfinavir," said Jeffrey P. Nadler, M.D., University of South Florida College of Medicine, Tampa, who presented the data at ICAAC. Further, 54 percent of patients in the 908 arm achieved a viral load less than 50 copies/mL, compared to 40 percent of patients taking nelfinavir.
Among people with a high viral load (>100,000 copies/mL) taking 908, 71 percent achieved a viral load <400 copies/mL and 42 percent achieved viral load <50 copies mL, versus 35 percent and 11 percent, respectively, of patients with high viral loads taking NFV, according to Dr. Nadler. Among patients with a viral load less than 100,000 copies/mL at baseline, 74 percent of patients in the 908 arm achieved an undetectable viral load, compared to 70 percent of patients in the nelfinavir arm.
Safety Results from NEAT
The incidence of dose limiting adverse events (AEs) and severe laboratory abnormalities was low in both groups. The only AE that was significantly different between the two groups was diarrhea, which was significantly more prevalent in patients on NFV (17 percent) than patients on 908 (5 percent). Most common AEs with 908 were allergy (8 percent), rash (8 percent) and nausea (5 percent).
"While the overall rates of discontinuations were similar in both study groups, more subjects withdrew due to insufficient viral response in the NFV group (11 percent) compared to the 908 group (2 percent)," said Dr. Nadler.
NEAT Study Demographics
The study population included:
A large proportion of patients with advanced HIV disease. Nearly 50
percent had viral loads greater than 100,000 copies at baseline, and
approximately 50 percent had CD4+ counts <200 cells/mm3, a criterion
that meets the definition of AIDS established by the Centers for
Disease Control and Prevention (CDC). Median CD4+ cell count was 214.
Further, approximately 20 percent had experienced a CDC Class C event
characteristic of advanced disease.
Gender diversity, with females representing 31 percent of the patient population.
Ethnic diversity, including a high proportion of Hispanic patients (44 percent) and patients of African descent (31 percent).
The investigational PI 908 is the calcium phosphate ester pro-drug of amprenavir. In the study reported at ICAAC, patients in the 908 group took 2 pills BID compared to 5 pills BID in the NFV group. It is being studied in several dosing presentations: twice a day (BID), once a day (QD) in combination with the PI-booster ritonavir, and twice a day (BID) with ritonavir. In the NEAT study, 908 was taken without food or fluid restrictions, while patients are advised to take nelfinavir with food.
Ongoing Clinical Trials with 908
NEAT, the first of three pivotal trials to support regulatory approval of 908, is a Phase III, randomized, open-label, parallel-group, 48-week study. The primary endpoint is the proportion of subjects with vRNA <400 c/mL at 24 and 48 weeks. More than 1,100 people are participating in Phase III trials to test the safety and efficacy of 908. In addition to the NEAT study, two other large-scale clinical trials of 908 are under way. The SOLO study is an open- label trial that has enrolled more than 650 HIV positive, treatment-naive patients. Participants have been randomized to receive either 1400 mg of 908 plus 200 mg ritonavir QD or 1250 mg of nelfinavir BID. All also receive ABC and 3TC, two nucleoside reverse transcriptase inhibitors. The trial is being conducted at more than 50 research centers worldwide and is designed to assess the safety and efficacy of each regimen over a period of 48 weeks. Results from the SOLO trial are expected to be presented at an upcoming medical conference.
The CONTEXT study is an open-label trial in PI-experienced subjects assessing 908 dosed at 700 mg BID in combination with 100 mg ritonavir, or 908 at 1400 mg QD in combination with 200 mg ritonavir, compared to a third treatment arm of 400 mg lopinavir/100 mg ritonavir BID. Participants also receive two nucleoside reverse transcriptase inhibitors. The trial is fully enrolled with more than 300 patients and is being conducted at more than 80 research centers worldwide. The study is assessing the safety and efficacy of each regimen at 24 and 48 weeks. Results from the CONTEXT trial are expected to be presented in 2003.
GlaxoSmithKline is one of the world`s leading research-based pharmaceutical and healthcare companies and an industry leader in HIV research and therapies. The company is engaged in basic research programs designed to investigate new targets to treat HIV.
Grüße
Skaya
Wie seht ihr die Pipeline z.Zt.?!
Thanx Kosto
Thanx Kosto
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