Purple Biotech (PPBT) ehemals KTOV (Mkap $16 M) ( Cash $17 M) US Zulassungsantrag diesen Quartal (Seite 86)

[Sven_Bonn]

toller Artikel.... aber Kitov selber sagt NICHTS... damit sagen sie aber schon viel...

[spoi]

https://www.globenewswire.com/news-release/2020/10/16/210979…

Daten unterstützen das Potenzial von NT219 zur Überwindung der Resistenz gegen Krebsmedikamente weiter

TEL AVIV, Israel, 16. Oktober 2020 (GLOBE NEWSWIRE) - Kitov Pharma Ltd. („Kitov“) (NASDAQ / TASE: KTOV), ein Unternehmen im klinischen Stadium, das erstklassige Therapien zur Überwindung der Tumorimmunevasion vorantreibt und Arzneimittelresistenz, angekündigte neue Daten, die den Wirkungsmechanismus von NT219 unterstützen, einem dualen Inhibitor, einem neuartigen kleinen Molekül, das auf IRS1 / 2 und STAT3 abzielt, werden in einer Videoaufzeichnung auf der AACR Special Virtual Conference von Forschern von Teligenetics and Metabolism vorgestellt. Universität Aviv. Die Daten wurden im Rahmen der Zusammenarbeit des Unternehmens mit Professor Ido Wolf, Leiter der Abteilung Onkologie, Tel Aviv Sourasky Medical Center, generiert.

Die neuen Daten zeigen, dass IRS2-amplifizierte Darmkrebszellen (CRC) die β-Catenin-Expression hochregulieren und die Behandlung mit NT219 die β-Catenin-Transkriptionsaktivität in diesen Zellen signifikant verringert. Darüber hinaus inhibierte NT219 die Lebensfähigkeit der Zellen in dosisabhängiger Weise deutlich. Darüber hinaus spielte IRS2 eine einzigartige Rolle bei der Förderung der Hirnmetastasierung von CRC, was darauf hindeutet, dass AKT- und β-Catenin-Wege stromabwärts von IRS2 an der Vermittlung des verstärkten aggressiven Phänotyps von IRS2-amplifizierten CRC-Zellen in der Mikroumgebung des Gehirns beteiligt sein könnten. Es wurde gezeigt, dass die β-Catenin-Signalübertragung durch Wnt eine Reihe verschiedener zellulärer Einflüsse hat. Neben der Zellproliferation über Proteinstabilisierung zur Förderung des Zellwachstums hat Wnt / β-Catenin eine Rolle beim Aufbau der Blut-Hirn-Schranke gezeigt und wirkt sich auf die Tumor-Mikroumgebung aus.Dzobo et al., 2019 ).

"Diese neuen Wirkmechanismusdaten unterstützen zusammen mit den überzeugenden Ergebnissen unserer präklinischen Studien zu NT219 die Gründe für die Kombination von NT219 mit verschiedenen zielgerichteten und immunonkologischen Ansätzen sowohl in Tumorgeweben des peripheren als auch des Nervensystems", sagte Dr. Bertrand Liang Ph.D., Chief Medical Officer von Kitov. „Wir nehmen derzeit Patienten in unsere klinische Phase-1/2-Studie mit NT219 als Monotherapie zur Behandlung fortgeschrittener solider Tumoren sowie in Kombination mit Cetuximab, einem monoklonalen Antikörper, der den epithelialen Wachstumsfaktorrezeptor (EGFR) blockiert, zur Behandlung von NT219 auf rezidivierende und / oder metastasierende solide Tumoren sowie Kopf- und Halskrebs oder kolorektales Adenokarzinom. Wir erwarten Top-Line-Daten aus dem ersten Teil dieser wichtigen Studie in der zweiten Hälfte des Jahres 2021. “

Zuvor abgeschlossene präklinische Studien zeigten die Fähigkeit von NT219, die Resistenz gegen Krebsmedikamente in von Patienten stammenden Xenotransplantatmodellen (PDX) verschiedener fortgeschrittener Krebsarten zu überwinden und die Resistenz gegen Pembrolizumab (Keytruda®) wiederherzustellen. Mäuse, die gleichzeitig mit einer Kombination aus Pembrolizumab und NT219 behandelt wurden, zeigten eine vollständige Blockade der Tumorprogression. In ähnlicher Weise sensibilisierte die Kombination von NT219 mit Cetuximab resistente Tumoren gegen diese Therapie.

[Sven_Bonn]

scheinen es einige Amis eilig zu haben...

Nasdaq

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[Sven_Bonn]

Antwort auf Beitrag Nr.: 65.406.567 von Sven_Bonn am 16.10.20 12:02:50

"so.. danach höre ich für heute auf... (es sei, denn BO :-) )"

--> sorry Leute ...😇😇😇

[Sven_Bonn]

ask im Direkthandel bei 3,92 Euro...

[Sven_Bonn]

https://seekingalpha.com/news/3622807-kitov-pharma-reports-n…

Heute geht es aber los...

[Sven_Bonn]

heute gehts aber ab..

https://seekingalpha.com/news/3622807-kitov-pharma-reports-n…

[Stoxtrayder]

Sehr schön 👌

Na, wenn der Buy-Out nicht kommt, würde ich sagen: Kursziel dausend! 😜

[Sven_Bonn]

https://www.stocktitan.net/news/KTOV/new-mechanism-of-action…

Data Further Support Potential of NT219 to Overcome Cancer Drug Resistance

TEL AVIV, Israel, Oct. 16, 2020 -- Kitov Pharma Ltd. ("Kitov") (NASDAQ/TASE: KTOV), a clinical-stage company advancing first-in-class therapies to overcome tumor immune evasion and drug resistance, announced new data supporting the mechanism of action of NT219, a dual inhibitor, novel small molecule targeting IRS1/2 and STAT3 is being presented in a video recorded presentation at the Epigenetics and Metabolism AACR Special Virtual Conference by researchers at Tel-Aviv University. The data was generated as part of the Company's collaboration with Professor Ido Wolf, Head of the Oncology Division, Tel Aviv Sourasky Medical Center.

The new data demonstrates IRS2-amplified colorectal cancer (CRC) cells upregulate ?-catenin expression, and treatment with NT219 significantly decreased the ?-catenin transcriptional activity in these cells. In addition, NT219 markedly inhibited cell viability in a dose-dependent manner. Moreover, there was a unique role for IRS2 in promoting brain metastasis of CRC, suggesting AKT and ?-catenin pathways downstream of IRS2 may be involved in mediating the enhanced aggressive phenotype of IRS2-amplified CRC cells in the brain microenvironment. ?-catenin signaling by Wnt has been shown to have a number of different cellular influences. Besides cellular proliferation via protein stabilization to promote cellular growth, Wnt/ ?-catenin has demonstrated a role in the establishment of the blood brain barrier and impacts the tumor microenvironment, associated with the therapeutic resistance of cancer cells (Dzobo et al, 2019).

"These new mechanism of action data, together with the compelling results from our preclinical studies of NT219, further support the rationale behind combining NT219 with various targeted and immune oncology approaches, both in peripheral and nervous system tumor tissues," said Bertrand Liang, M.D., Ph.D., Chief Medical Officer of Kitov. "We are currently enrolling patients in our Phase 1/2 clinical trial of NT219 as monotherapy for the treatment of advanced solid tumors, as well as in combination with cetuximab, an epithelial growth factor receptor (EGFR) blocking monoclonal antibody, for the treatment of recurrent and/or metastatic solid tumors and head and neck cancer or colorectal adenocarcinoma. We expect top-line data from the first part of this important study in the second half of 2021."

Previously completed preclinical studies demonstrated NT219's ability to overcome cancer drug resistance in patient-derived xenograft (PDX) models of various advanced cancer types, and to revert resistance to pembrolizumab (Keytruda(R)). Mice treated concomitantly with a combination of pembrolizumab and NT219 demonstrated complete blockage of tumor progression. Similarly, the combination of NT219 with cetuximab sensitized resistant tumors to this therapy.

About Kitov Pharma
Kitov Pharma Ltd. ("Kitov"; NASDAQ/TASE: KTOV) is a clinical-stage company focusing on advancing first-in-class therapies to overcome tumor immune evasion and drug resistance, to create successful long-lasting treatments for people with cancer. Kitov's oncology pipeline includes NT219 and CM24. NT219 is a small molecule targeting the novel cancer drug resistance pathways IRS1/2 and STAT3. Kitov is currently advancing NT219 as a monotherapy treatment of advanced solid tumors and in combination with cetuximab for the treatment of recurrent or metastatic squamous cell carcinoma of head and neck cancer (SCCHN) in a phase 1/2 study. CM24 is a monoclonal antibody blocking CEACAM1, a novel immune checkpoint that supports tumor immune evasion and survival through multiple pathways. Kitov plans to advance CM24 as a combination therapy with anti-PD1 checkpoint inhibitors in selected cancer indications in a phase 1 study followed by a phase 2 for the treatment of non-small cell lung cancer NSCLC and pancreatic cancer. Kitov has entered into a clinical collaboration agreement with Bristol Myers Squibb Company for the planned phase 1/2 clinical trials to evaluate the combination of CM24 with the PD-1 inhibitor nivolumab (Opdivo(R)). Kitov is also the owner of Consensi(R), a fixed-dose combination of celecoxib and amlodipine besylate, for the simultaneous treatment of osteoarthritis pain and hypertension that was approved by the FDA for marketing in the U.S. Consensi(R) is being sold in the U.S. by Burke Therapeutics, the marketing partner of Kitov's U.S. distributor, Coeptis Pharmaceuticals. Kitov has also partnered to commercialize Consensi in China and South Korea. The company is headquartered in Tel Aviv, Israel. For more information, please visit http://www.kitovpharma.com.

Forward-Looking Statements and Kitov's Safe Harbor Statement
Certain statements in this press release that are forward-looking and not statements of historical fact are forward looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements that are not statements of historical fact, and may be identified by words such as "believe", "expect", "intend", "plan", "may", "should", "could", "might", "seek", "target", "will", "project", "forecast", "continue" or "anticipate" or their negatives or variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters. You should not place undue reliance on these forward-looking statements, which are not guarantees of future performance. Forward-looking statements reflect our current views, expectations, beliefs or intentions with respect to future events, and are subject to a number of assumptions, involve known and unknown risks, many of which are beyond our control, as well as uncertainties and other factors that may cause our actual results, performance or achievements to be significantly different from any future results, performance or achievements expressed or implied by the forward-looking statements. Important factors that could cause or contribute to such differences include, among others, risks relating to: the plans, strategies and objectives of management for future operations; product development for NT219 and CM24; the process by which early stage therapeutic candidates such as NT219 and CM24 could potentially lead to an approved drug product is long and subject to highly significant risks, particularly with respect to a joint development collaboration; the fact that drug development and commercialization involves a lengthy and expensive process with uncertain outcomes; our ability to successfully develop and commercialize our pharmaceutical products; the expense, length, progress and results of any clinical trials; the impact of any changes in regulation and legislation that could affect the pharmaceutical industry; the difficulty in receiving the regulatory approvals necessary in order to commercialize our products; the difficulty of predicting actions of the U.S. Food and Drug Administration or any other applicable regulator of pharmaceutical products; the regulatory environment and changes in the health policies and regimes in the countries in which we operate; the uncertainty surrounding the actual market reception to our pharmaceutical products once cleared for marketing in a particular market; the introduction of competing products; patents obtained by competitors; dependence on the effectiveness of our patents and other protections for innovative products; our ability to obtain, maintain and defend issued patents; the commencement of any patent interference or infringement action against our patents, and our ability to prevail, obtain a favorable decision or recover damages in any such action; and the exposure to litigation, including patent litigation, and/or regulatory actions, and other factors that are discussed in our Annual Report on Form 20-F for the year ended December 31, 2019 and in our other filings with the U.S. Securities and Exchange Commission ("SEC"), including our cautionary discussion of risks and uncertainties under "Risk Factors" in our Registration Statements and Annual Reports. These are factors that we believe could cause our actual results to differ materially from expected results. Other factors besides those we have listed could also adversely affect us. Any forward-looking statement in this press release speaks only as of the date which it is made. We disclaim any intention or obligation to publicly update or revise any forward-looking statement or other information contained herein, whether as a result of new information, future events or otherwise, except as required by applicable law. You are advised, however, to consult any additional disclosures we make in our reports to the SEC, which are available on the SEC's website, http://www.sec.gov.

[Sven_Bonn]

okay, einen noch....

Selective COX-2 Inhibitor Market 2020 Increasing Demand, Growth Analysis and Strategic Outlook

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Top Key Players in the Global Selective COX-2 Inhibitor Market: Crystal genomics, Kitov Pharmaceuticals, Merck & Co, Boehringer Ingelheim, Tragara Pharmaceuticals ....

Quelle: https://markets.financialcontent.com/stocks/news/read/404990…