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[109]

Remune [abstract LB-21]


The search for effective immune modulators for HIV disease is important because antiretroviral therapies have limitations for optimally controlling HIV over the long term. Recently, a large-scale study of Remune, a therapeutic injectable vaccine composed of inactivated gp120-depleted HIV-1, was stopped by its Data & Safety Monitoring Board when no difference in clinical progression or HIV RNA levels was detected between the treatment and placebo arms.

Kahn and colleagues enrolled 2,527 patients with CD4 counts between 300 and 550 cells/mm3 and no AIDS defining conditions (except KS) into a multicenter study comparing Remune to placebo. The average follow up time was 88.7 weeks. Local injection site reactions were the only significant adverse reactions observed. In the Remune treatment group, 44 patients experienced clinical disease progression, versus 46 in the placebo group. This was not statistically significant. Overall, the progression rate was 2.1 events per 100 person years of follow up. It was speculated that the effectiveness of HAART may have obscured any benefit derived from Remune

Quelle:
http://hivinsite.ucsf.edu/topics/research_advances/2098.441d…

[moses_XX]

Hallo 109,

bitte sei so gut und erkläre mir als einem "nicht-Fachkundigen" was der Bericht sagt.

Danke

Gruß und Erfolg

[guntis]

ich hab da immer wieder das gleiche Problem. Ich hatte zwar in der Schule Englischunterricht, aber bei solchen Texten muß ich leider passen.

Gibt es eigentlich nicht die möglichkeit diese Texte zu übersetzen?

Gruß
guntis

[109]

oops, wenn ich mich nicht blamieren will brauche ich dafür locker
1 Std.